Friday, January 9, 2026 1/9/2026

The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancer

Award Number: R01CA240965
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/07/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancer - Patients with high-grade serous ovarian cancer (HGSOC) are frequently diagnosed with extensive metastatic disease, resulting in a poor prognosis. In HGSOC, metastasis occurs primarily by transcoelomic spread, where tumor cells detach from the primary tumor, float through the peritoneal fluid, and attach to the mesothelial layer to form new metastases. Tumor cells in patient ascites exist as single cells or in multi-cellular aggregates similar in size to experimental spheroids. We hypothesize that single cell and aggregate-based metastasis are distinct processes in HGSOC transcoelomic spread. To test this hypothesis, we will utilize a combination of engineering-based approaches (in vitro culture systems, multivariate modeling, computational fluid dynamics) and biological methods (molecular and cellular assays, analysis of patient samples, xenograft models). This proposal leverages a diverse, collaborative team that includes experts in engineering, biology, and the clinical presentation of HGSOC. Completion of the proposed studies will result in an improved understanding of mechanisms regulating transcoelomic spread and identification of potential targets for future work to control metastatic spread.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	5	11/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $509,929 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	5	12/18/2024	NON-COMPETING CONTINUATION	$458,937
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	001	5	6/13/2025	NON-COMPETING CONTINUATION	$50,992
														Subtotal = $509,929

Issue Date FY: 2024 ( Subtotal = $688,284 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	002	4	9/17/2024	SUPPLEMENT FOR EXPANSION	$194,041
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	4	12/21/2023	NON-COMPETING CONTINUATION	$468,230
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	001	4	4/16/2024	NON-COMPETING CONTINUATION	$26,013
														Subtotal = $688,284

Issue Date FY: 2023 ( Subtotal = $517,439 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	3	1/27/2023	NON-COMPETING CONTINUATION	$517,439
														Subtotal = $517,439

Issue Date FY: 2022 ( Subtotal = $496,312 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	001	2	6/14/2022	NON-COMPETING CONTINUATION	$40,516
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	2	1/21/2022	NON-COMPETING CONTINUATION	$455,796
														Subtotal = $496,312

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	1	8/10/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $505,123 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	1	8/7/2020	NEW	$505,123
														Subtotal = $505,123

Grand Total All Awards = $2,717,087

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The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancer

Award Number: R01CA240965

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/07/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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