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Health Consequences of Fear of Cancer Recurrence in Breast Cancer Survivors and Partners

Award Number: R01CA240727
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Health Consequences of Fear of Cancer Recurrence in Breast Cancer Survivors and Partners - Project Summary/Abstract Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer mortality among women in the US (ACS, 2017). High baseline prevalence, increasing screening rates, and better treatments have all contributed to a large population of BC survivors that will increase from an estimated 3.5 million in 2016 to a projected 4.5 million in the next 10 years (ACS, 2017). Multiple studies document fear of cancer recurrence (FCR) as a top long- term concern of both cancer survivors and their significant others that impacts on quality of life. Despite an increasing emphasis on FCR in the literature, a critical gap in knowledge is how FCR can produce health behavior consequences with known implications for long-term health outcomes. The overall objective of this proposal is to examine medication adherence, physical activity/sedentary behavior, and sleep as three proximal health behavior outcomes that are modifiable and have been linked to recurrence (for patients) as well as morbidity and mortality (for both patients and spouses/partners). Moreover, FCR and health behaviors are concordant within-couple reflecting an interdependent and interpersonal context that, if ignored, would limit a complete understanding of important health consequences of FCR. Preliminary data from a recently completed NCI-funded R21 project form the scientific premise and the basis of power analyses for the specific and exploratory aims. Using longitudinal, within-person methods as well as individual and dyadic multilevel structural equation modeling, we will pursue the following hypothesis-driven aims: 1) identify the consequences of FCR for physical activity; 2) identify the consequences of FCR for adherence to adjuvant hormonal treatment; and 3) identify the consequences of FCR for sleep quantity and quality. Finally, using biomarkers of cardio- metabolic health risk (i.e., HbA1c, lipids, insulin resistance, body composition), we will explore the links between the targeted health behaviors and these health outcomes. A long-term objective of the proposed work is to influence the development and refinement of interventions for FCR and health behaviors ultimately increasing optimal mental and physical well-being of cancer survivors and their spouses/partners.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $643,177 )
2025	2025	UNIVERSITY OF DELAWARE	550 S COLLEGE AVE	NEWARK	DE	19713	NEW CASTLE	USA	Cancer Cause and Prevention Research	001	5	5/22/2025	NON-COMPETING CONTINUATION	$64,317
2025	2025	UNIVERSITY OF DELAWARE	550 S COLLEGE AVE	NEWARK	DE	19713	NEW CASTLE	USA	Cancer Cause and Prevention Research	000	5	3/17/2025	NON-COMPETING CONTINUATION	$578,860
														Subtotal = $643,177

Issue Date FY: 2024 ( Subtotal = $611,003 )
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Cancer Cause and Prevention Research	001	4	4/17/2024	NON-COMPETING CONTINUATION	$32,156
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Cancer Cause and Prevention Research	000	4	4/1/2024	NON-COMPETING CONTINUATION	$578,847
														Subtotal = $611,003

Issue Date FY: 2023 ( Subtotal = $630,284 )
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Cancer Cause and Prevention Research	000	3	3/31/2023	NON-COMPETING CONTINUATION	$630,284
														Subtotal = $630,284

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Cancer Cause and Prevention Research	000	2	4/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $645,009 )
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Cancer Cause and Prevention Research	000	2	3/26/2021	NON-COMPETING CONTINUATION	$645,009
														Subtotal = $645,009

Issue Date FY: 2020 ( Subtotal = $672,861 )
2020	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Cancer Cause and Prevention Research	000	1	3/20/2020	NEW	$672,861
														Subtotal = $672,861

Grand Total All Awards = $3,202,334

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Health Consequences of Fear of Cancer Recurrence in Breast Cancer Survivors and Partners

Award Number: R01CA240727

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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