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Communicating about Nicotine and Differential Risks of Tobacco Products in Priority Populations

Award Number: R01CA239308
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Communicating about Nicotine and Differential Risks of Tobacco Products in Priority Populations - ABSTRACT Tobacco use continues to disproportionately harm priority populations, such as smokers with mental health conditions and people from low socioeconomic status (SES) groups. The US Food and Drug Administration (FDA) is moving forward with a groundbreaking plan to reduce tobacco-related death and disease by lowering nicotine in combusted cigarettes to minimally addictive levels. To maximize the effectiveness of this potentially life-saving policy, its implementation needs to be accompanied by messages that address misperceptions about very low nicotine cigarettes (VLNCs; e.g., that VLNCs are less harmful than regular cigarettes). Past randomized clinical trials (RCTs) with VLNCs found that they are less addictive than cigarettes, reduce the number of cigarettes smoked per day, and have similar beneficial effects among priority populations as in the general population. However, past RCTs with VLNCs did not include messages about the products or policy. Emerging studies have begun to investigate messages about VLNCs, but so far they did not examine the effects of messages on behavior and were all hypothetical, with messages unaccompanied by use of the actual product. We propose to take the next step and bring together two streams of research (RCTs of VLNCs and messages about VLNCs) that have remained disparate but need to be combined to more closely resemble reduced nicotine policy implementation in the real world. We will address three specific aims: (1) Develop targeted messages about reduced nicotine in combusted tobacco products for smokers with serious psychological distress (SPD) and socioeconomically disadvantaged smokers using qualitative focus groups. (2) Test the impact of messages about VLNCs on tobacco use behaviors in an RCT with smokers with SPD, low-SES, and smokers who are neither. After 1-week baseline using normal nicotine content cigarettes, participants will be randomized into treatment (VLNCs and messages) or control (VLNCs only) condition. Participants in the treatment condition will be exposed to messages as inserts (small printed leaflets) in cigarette packs and print and video ads during weekly in-person visits. All participants will use VLNCs for 4 weeks and complete daily logs and weekly in-person visits. (3) Assess experiences with VLNCs and messages among the RCT participants in focus groups following the completion of the RCT. The results will contribute to the science that informs FDA regulatory actions around product review, product standards, and public education on nicotine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $776,274 )
2025	2025	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	003	5	1/23/2025	NON-COMPETING CONTINUATION	$776,274
2025	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	4	1/14/2025	COMPETING CONTINUATION	$0
2025	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	4	1/17/2025	COMPETING CONTINUATION	$0
2025	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	1/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $776,274

Issue Date FY: 2024 ( Subtotal = $804,341 )
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	4	2/7/2024	COMPETING CONTINUATION	$0
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	4	2/29/2024	COMPETING CONTINUATION	$0
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	4	1/31/2024	COMPETING CONTINUATION	$804,341
														Subtotal = $804,341

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	6/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $514,395 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	003	3	9/20/2021	SUPPLEMENT FOR EXPANSION	$28,618
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	3	8/10/2021	NON-COMPETING CONTINUATION	$433,205
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	3	8/12/2021	SUPPLEMENT FOR EXPANSION	$52,572
2021	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	4/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $514,395

Issue Date FY: 2020 ( Subtotal = $453,029 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	8/3/2020	NON-COMPETING CONTINUATION	$453,029
														Subtotal = $453,029

Issue Date FY: 2019 ( Subtotal = $465,673 )
2019	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	9/16/2019	NEW	$465,673
														Subtotal = $465,673

Grand Total All Awards = $3,013,712

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Communicating about Nicotine and Differential Risks of Tobacco Products in Priority Populations

Award Number: R01CA239308

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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