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Macro-vasculature: A Novel Image Biomarker of Lung Cance

Award Number: R01CA237277
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/13/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Macro-vasculature: A Novel Image Biomarker of Lung Cance - ABSTRACT Lung cancer remains the leading cause of cancer related deaths in the United States and worldwide. The high mortality associated with lung cancer is in part due to underutilization of and limited access to lung cancer screening that impedes early diagnosis. The apprehension of some clinicians and policymakers towards lung cancer screening with low-dose computed tomography (LDCT) exams is based on concerns of lead-time bias and high false-positive rate. The development of a robust lung cancer biomarker that reduces screen-detected false positives and improves classification of indeterminate nodules would relieve some of the concerns related to lung cancer screening. Although investigations show that screening with LDCT scans may reduce lung cancer mortality by 20% compared to chest x-ray, it is reported that ~96% of suspicious findings (mostly indeterminate nodules) turn out to be non-cancerous (false positives). Clinical management of screen-detected indeterminate nodules often leads to unnecessary, costly, and potentially harmful follow-up procedures (e.g., follow-up CT scan, positron emission tomography (PET)/CT exam, invasive biopsies). We have developed an exciting and novel image-based macro-vasculature feature to discriminate benign from malignant nodules. We propose to further develop the feature and validate it across a range of CT protocols and scans from other institutions. We will also integrate the macro-vasculature features with clinical information (e.g., age, gender, smoking history, lung function) and evaluate the model's ability to discriminate benign from malignant screen-detected indeterminate nodules. We will investigate if a radiologist's classification of indeterminate nodules improves with the output of the integrative model compared to classification without the integrative model. The success of this project may lead to a novel and robust lung cancer biomarker to accurately assess screen-detected indeterminate nodules that can significantly reduce the number of unnecessary follow-up procedures during lung cancer screening.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$2,236 )
2026	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	5	4/27/2026	NON-COMPETING CONTINUATION	-$2,236
														Subtotal = -$2,236

Issue Date FY: 2024 ( Subtotal = $431,503 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	5	4/16/2024	NON-COMPETING CONTINUATION	$22,709
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	5	12/22/2023	NON-COMPETING CONTINUATION	$408,794
														Subtotal = $431,503

Issue Date FY: 2023 ( Subtotal = $671,711 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	4	1/27/2023	NON-COMPETING CONTINUATION	$671,711
														Subtotal = $671,711

Issue Date FY: 2022 ( Subtotal = $625,668 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	002	3	5/10/2022	NON-COMPETING CONTINUATION	$51,604
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	3	12/8/2021	NON-COMPETING CONTINUATION	$580,535
2022	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	2	10/12/2021	SUPPLEMENT FOR EXPANSION	-$6,471
														Subtotal = $625,668

Issue Date FY: 2021 ( Subtotal = $649,662 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	002	2	7/16/2021	SUPPLEMENT FOR EXPANSION	$237,953
2021	2021	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	2	1/25/2021	NON-COMPETING CONTINUATION	$20,584
2021	2021	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	2	12/2/2020	NON-COMPETING CONTINUATION	$391,125
														Subtotal = $649,662

Issue Date FY: 2020 ( Subtotal = $415,606 )
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	1	1/13/2020	NEW	$415,606
														Subtotal = $415,606

Grand Total All Awards = $2,791,914

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Macro-vasculature: A Novel Image Biomarker of Lung Cance

Award Number: R01CA237277

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/13/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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