Tuesday, July 1, 2025 7/1/2025

Exploiting Public Metagenomic Data to Uncover Cancer-Microbiome Relationships

Award Number: R01CA230551
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Exploiting Public Metagenomic Data to Uncover Cancer-Microbiome Relationships - Abstract Dysbiosis of the host microbiome is now recognized as a hallmark of cancer and a factor in the systemic response to immunotherapy. While a large volume of literature and data resources on microbiome research are available, systemic comparison and analysis are limited due to the heterogeneity in data and reporting schema. To enable rapid and cost-effective elucidation of the roles of microorganisms in the etiology and progression of cancer, we have developed high-quality harmonized databases of public microbiome data and microbial signatures. This proposal expands and creates new features of these microbiome databases through four aims. First, it will enhance the analytic scope of BugSigDB, a Semantic Mediawiki for manual curation and review of microbial signatures by incorporating microbial physiologies and morphologies, predicted metabolic functions, automatic identification of similar signatures, and creation of user-friendly Bug Set Enrichment Analysis workflows. Second, it will establish the next generation of curatedMetagenomicData, a microbiome database of large-scale manual curation and uniformly processed shotgun sequencing data, supporting FAIR principles. We will create a federated, ontology-based curation system and distributed computing metagenomic profiling workflow, both applicable to all Sequence Read Archive (SRA) records. Third, it will expand curatedMetagenomicData and BugSigDB with data from thousands of published studies and perform meta-analyses using these resources. Lastly, we will mobilize hundreds of data curators from diverse backgrounds by participating in established internship programs and mobilize the microbiome research community to adopt reporting standards for publication. This contribution is significant because it increases the likelihood of developing effective public health interventions to prevent and detect microbiota-linked cancers by providing methods for improved mechanistic interpretation of microbiome studies, extracting new information from published raw metagenomic shotgun sequencing data and metadata, and enabling re-use of existing data by a much broader range of researchers and methodologies. The proposed research is innovative because it identifies and corrects important deficiencies in how microbiome data are published, increasing the utility of public data and published results on a large scale by other research teams.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 W 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	001	6	4/25/2025	COMPETING CONTINUATION	$9,122
2025	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 W 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	000	5	4/25/2025	NON-COMPETING CONTINUATION	-$9,122
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $427,476 )
2024	2024	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 W 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	001	6	9/5/2024	COMPETING CONTINUATION	$427,476
2024	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 W 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	000	5	8/28/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $427,476

Issue Date FY: 2023 ( Subtotal = $383,112 )
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 WEST 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	000	5	8/9/2023	NON-COMPETING CONTINUATION	$383,112
														Subtotal = $383,112

Issue Date FY: 2022 ( Subtotal = $535,319 )
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 WEST 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	001	4	8/3/2022	NON-COMPETING CONTINUATION	$387,513
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 WEST 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	002	4	9/13/2022	NON-COMPETING CONTINUATION	$147,806
2022	2021	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 WEST 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	000	3	1/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $535,319

Issue Date FY: 2021 ( Subtotal = $404,403 )
2021	2021	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 WEST 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	001	3	6/22/2021	NON-COMPETING CONTINUATION	$404,403
2021	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	55 WEST 125TH ST FL 7	NEW YORK	NY	10027	NEW YORK	USA	Cancer Cause and Prevention Research	000	2	3/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $404,403

Grand Total All Awards = $1,750,310

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Exploiting Public Metagenomic Data to Uncover Cancer-Microbiome Relationships

Award Number: R01CA230551

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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