Tuesday, September 16, 2025 9/16/2025

A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging

Award Number: R01CA214515
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging - PROJECT SUMMARY/ABSTRACT This grant application proposes to use the unique stationary Multi-X-ray-source Array (MXA) technology developed and applied to digital breast tomosynthesis (DBT) under our current R01 to: 1) significantly improve DBT image quality by extending the MXA technology to produce a clinically practical two-dimensional (2D) MXA and 2) demonstrate a capable and fully characterized 2D MXA DBT system to use for clinical trials under a follow-on R01 Academic–Industrial Partnership program. By the time the first film-based commercial tomosynthesis systems were developed in the 1970s, it was realized that 2D motion of the X-ray source significantly improved image quality relative to 1D motion due to better blurring of the shadows of structures both above and below the plane of interest. All existing commercial DBT systems use 1D motion because 2D mechanical motion is complicated and expensive and would significantly increase scan times which are already too long at 4 to 25 s with the 1D motion-based systems. Compare this to mammography, where it is preferred to keep scan times under 2 s to minimize patient-motion artifacts. Extending MXA technology to make 2D breast tomosynthesis practical – by meeting scan time constraints – will provide superior performance compared with all commercial breast tomosynthesis systems on the market today, while at the same time decreasing system size and cost. The net result would be a significant increase in the capability of DBT systems and a broadening of their availability to bring better care to more people sooner. The Specific Aims of this application are: Aim 1. Use modeling and experiments to design the 2D MXA-DBT prototype system Aim 2. Build 2D MXA DBT prototype system Aim 3. Evaluate performance of 2D MXA DBT prototype system


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $391,867 )
2025	2025	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Detection and Diagnosis Research	000	9	8/22/2025	NON-COMPETING CONTINUATION	$391,867
														Subtotal = $391,867

Issue Date FY: 2024 ( Subtotal = $372,741 )
2024	2024	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Detection and Diagnosis Research	000	8	8/1/2024	NON-COMPETING CONTINUATION	$372,741
														Subtotal = $372,741

Issue Date FY: 2023 ( Subtotal = $367,066 )
2023	2023	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Cancer Detection and Diagnosis Research	004	7	8/16/2023	NON-COMPETING CONTINUATION	$367,066
2023	2022	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	000	5	2/11/2023	COMPETING CONTINUATION	-$430,799
2023	2022	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	002	5	6/14/2023	COMPETING CONTINUATION	-$88,728
2023	2022	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Cancer Detection and Diagnosis Research	001	6	2/11/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$430,799
2023	2022	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Cancer Detection and Diagnosis Research	003	6	6/14/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$88,728
														Subtotal = $367,066

Issue Date FY: 2022 ( Subtotal = $461,241 )
2022	2022	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	004	5	7/5/2022	COMPETING CONTINUATION	$519,527
2022	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	003	4	6/16/2022	NON-COMPETING CONTINUATION	-$58,286
2022	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	001	4	5/16/2022	NON-COMPETING CONTINUATION	-$80,165
2022	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	000	4	12/14/2021	NON-COMPETING CONTINUATION	$0
2022	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	002	4	6/2/2022	NON-COMPETING CONTINUATION	$80,165
														Subtotal = $461,241

Issue Date FY: 2020 ( Subtotal = $360,077 )
2020	2020	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	000	4	2/7/2020	NON-COMPETING CONTINUATION	$360,077
														Subtotal = $360,077

Issue Date FY: 2019 ( Subtotal = $340,766 )
2019	2019	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	000	3	2/21/2019	NON-COMPETING CONTINUATION	$340,766
														Subtotal = $340,766

Issue Date FY: 2018 ( Subtotal = $349,610 )
2018	2018	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	000	2	2/14/2018	NON-COMPETING CONTINUATION	$314,647
2018	2018	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	001	2	5/21/2018	NON-COMPETING CONTINUATION	$34,963
														Subtotal = $349,610

Issue Date FY: 2017 ( Subtotal = $349,685 )
2017	2017	SRI INTERNATIONAL	333 RAVENSWOOD AVE	MENLO PARK	CA	94025	SAN MATEO	USA	Cancer Detection and Diagnosis Research	000	1	3/9/2017	NEW	$349,685
														Subtotal = $349,685

Grand Total All Awards = $2,993,053

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A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging

Award Number: R01CA214515

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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