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Detection of metastases in lymph nodes using quantitative ultrasound

Award Number: R01CA192407
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2015
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Detection of metastases in lymph nodes using quantitative ultrasound - ? DESCRIPTION (provided by applicant): This application proposes an Academic-Industrial Partnership (AIP) consisting of Riverside Research (RR) in New York, NY, as the primary partner in collaboration with the GE Global Research Center (GE) in Niskayuna, NY, as the industrial partner, and with the Stony Brook Medical (SBM) affiliated with the State University of New York in Stony Brook, NY, and the Kuakini Medical Center (KMC) affiliated with the University of Hawaii in Honolulu, HI, as the clinical/academic partners. The proposed project addresses the need for reliable, highly sensitive means of detecting metastases to lymph nodes (LNs) in order to correctly stage and optimally treat cancer. Accordingly, we seek to validate existing encouraging results obtained by RR and KMC using quantitative-ultrasound (QUS) methods for detecting metastases in LNs by applying and evaluating these promising methods using a far larger number of LNs and including a far broader range of cancer types from a more-diverse patient population than has been possible in studies to date. Validation efforts will include development, deployment and evaluation of a pre-prototype ultrasonic instrument for QUS-based detection and imaging of metastases in the pathology laboratory. Successful validation will establish a foundation for translation of the QUS methods into a compact, low-cost instrument for metastases detection in dissected LNs to be used in the pathology laboratory or possibly in the operating room. Successful validation also will establish the foundation for a subsequent instrument that can detect and image nodal metastases intra-operatively in the operating room or pre-operatively in the examination room. The AIP partners will synergize capabilities in the following general ways: RR will provide project oversight and coordination and will apply, refine, and test the QUS methods; GE will provide ultrasound (US) instrumentation by designing, fabricating, and characterizing a pre-prototype device; SBM and KMC will provide clinical support by recruiting patients and acquiring US and histological data from dissected LNs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM ST 9TH FL	NEW YORK	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	5	12/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $609,145 )
2019	2019	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM ST 9TH FL	NEW YORK	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	5	7/26/2019	NON-COMPETING CONTINUATION	$609,145
														Subtotal = $609,145

Issue Date FY: 2018 ( Subtotal = $627,097 )
2018	2018	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM ST 9TH FL	NEW YORK	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	4	7/23/2018	NON-COMPETING CONTINUATION	$627,097
														Subtotal = $627,097

Issue Date FY: 2017 ( Subtotal = $680,776 )
2017	2017	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM ST 9TH FL	NEW YORK	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	3	7/18/2017	NON-COMPETING CONTINUATION	$680,776
														Subtotal = $680,776

Issue Date FY: 2016 ( Subtotal = $706,909 )
2016	2016	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	2	8/4/2016	NON-COMPETING CONTINUATION	$706,909
														Subtotal = $706,909

Issue Date FY: 2015 ( Subtotal = $644,493 )
2015	2015	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	1	7/31/2015	NEW	$644,493
														Subtotal = $644,493

Grand Total All Awards = $3,268,420

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Detection of metastases in lymph nodes using quantitative ultrasound

Award Number: R01CA192407

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2015

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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