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Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery Guidance

Award Number: R01CA187427
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery Guidance - PROJECT SUMMARY In this competitive renewal for R01 CA187427, we will continue to advance label-free Fluorescence Lifetime Imaging (FLIm) to enhance the functionality of the widely-used da Vinci Surgical platform with an emphasis on Trans-Oral-Robotic-Surgery (TORS). UC Davis has pioneered the intra-operative use of FLIm and our partner, Intuitive Surgical, is the global leader in robotic-assisted surgery. To date, we have demonstrated a) the synergetic integration of a point-scanning FLIm device with the da Vinci Surgical System (first-of-its-kind); b) the potential of this approach to improve surgical decision-making during TORS without modifying conventional clinical protocols; and c) the utility of FLIM-derived parameters detecting biochemical and metabolic characteristics to distinguish oral and oropharyngeal cancer in real-time from surrounding normal tissue in patients in-situ.. We also developed innovative methods for real-time dynamic augmentation of imaging parameters on the surgical field of view. Capitalizing on the major accomplishments and knowledge gained under the current R01, the overarching objective of this renewal application is to 1) demonstrate FLIm’s diagnostic value in prospective studies by accounting for biological/experimental variables identified as critical under the current R01 and leveraging pre-operative imaging and clinical information and 2) enhance the visualization of FLIm-based classifiers on the surgeon console for real-time intraoperative feedback. To accomplish our overall objective, we propose three specific aims: Aim 1. Expand the FLIm database and develop tissue-type classifiers (retrospective analysis) accounting for biological variables (e.g., patient age/sex, tumor origin/location) and experimental situations (e.g., epithelial surface vs deep margins, tumors of an unknown primary) and the pre- operative imaging (CT, PET) features used in surgical planning. Aim 2. Develop, validate and perform regulatory activities for enhanced FLIm data visualization in support of prospective clinical studies. Aim 3. Validate FLIm as a means of real-time intraoperative TORS guidance in a prospective study analysis. In summary, this study will demonstrate the clinical feasibility and utility of FLIm for intraoperative real-time assessment of oral and oropharyngeal cancer surgical margins. The acquired FLIm parameter database will enable subsequent large clinical trials for automated tissue classification and diagnostic prediction. While the focus of this application is on TORS surgeries, the label-free FLIm-based tissue assessment, characterized by simple, fast and flexible data acquisition and display, can be broadly applied to other procedures as the da Vinci Surgical System is used in a wide range of tumor surgeries including urologic, colorectal, gynecologic, and thoracic cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $645,998 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	11	5/22/2025	NON-COMPETING CONTINUATION	$645,998
														Subtotal = $645,998

Issue Date FY: 2024 ( Subtotal = $615,623 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	10	5/1/2024	NON-COMPETING CONTINUATION	$615,623
														Subtotal = $615,623

Issue Date FY: 2023 ( Subtotal = $636,867 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	9	4/25/2023	NON-COMPETING CONTINUATION	$636,867
														Subtotal = $636,867

Issue Date FY: 2022 ( Subtotal = $638,507 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	8	5/20/2022	NON-COMPETING CONTINUATION	$638,507
														Subtotal = $638,507

Issue Date FY: 2021 ( Subtotal = $633,669 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	003	7	8/31/2021	COMPETING CONTINUATION	$28,118
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	001	7	4/16/2021	COMPETING CONTINUATION	$633,669
2021	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	002	6	8/31/2021	NON-COMPETING CONTINUATION	-$28,118
2021	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	6	4/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $633,669

Issue Date FY: 2019 ( Subtotal = $188,788 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	6	9/6/2019	NON-COMPETING CONTINUATION	$188,788
														Subtotal = $188,788

Issue Date FY: 2018 ( Subtotal = $370,323 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	5	9/7/2018	NON-COMPETING CONTINUATION	$370,323
														Subtotal = $370,323

Issue Date FY: 2017 ( Subtotal = $15,474 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	4	9/13/2017	NON-COMPETING CONTINUATION	$15,474
														Subtotal = $15,474

Issue Date FY: 2016 ( Subtotal = $301,268 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	3	8/29/2016	NON-COMPETING CONTINUATION	$301,268
														Subtotal = $301,268

Issue Date FY: 2015 ( Subtotal = $301,416 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	2	7/29/2015	NON-COMPETING CONTINUATION	$301,416
														Subtotal = $301,416

Issue Date FY: 2014 ( Subtotal = $298,371 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cancer Detection and Diagnosis Research	000	1	9/12/2014	NEW	$298,371
														Subtotal = $298,371

Grand Total All Awards = $4,646,304

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Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery Guidance

Award Number: R01CA187427

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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