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3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

Award Number: R01CA160850
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2012
PERIOD OF PERFORMANCE END DATE: 12/31/2017

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3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging - DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	OPTOSONICS, INC.	108 STRAIGHT ROAD	ORIENTAL	NC	28571	PAMLICO	USA	Cancer Detection and Diagnosis Research	000	5	3/15/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	OPTOSONICS, INC.	108 STRAIGHT ROAD	ORIENTAL	NC	28571	PAMLICO	USA	Cancer Detection and Diagnosis Research	001	5	12/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$70,891
2017	2015	OPTOSONICS, INC.	108 STRAIGHT ROAD	ORIENTAL	NC	28571	PAMLICO	USA	Cancer Detection and Diagnosis Research	000	4	12/28/2016	NON-COMPETING CONTINUATION	-$70,891
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $646,441 )
2016	2016	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	000	5	3/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$646,441
														Subtotal = $646,441

Issue Date FY: 2015 ( Subtotal = $654,907 )
2015	2015	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	000	4	4/1/2015	NON-COMPETING CONTINUATION	$654,907
														Subtotal = $654,907

Issue Date FY: 2014 ( Subtotal = $640,051 )
2014	2014	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	000	3	3/26/2014	NON-COMPETING CONTINUATION	$640,051
														Subtotal = $640,051

Issue Date FY: 2013 ( Subtotal = $646,824 )
2013	2013	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	002	2	6/27/2013	NON-COMPETING CONTINUATION	$326,815
2013	2013	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	001	2	3/8/2013	NON-COMPETING CONTINUATION	$300,135
2013	2012	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	000	1	3/5/2013	NEW	$19,874
														Subtotal = $646,824

Issue Date FY: 2012 ( Subtotal = $654,145 )
2012	2012	OPTOSONICS, INC	351 W 10th St Ste 250	Indianapolis	IN	46202	MARION	USA	Cancer Detection and Diagnosis Research	000	1	5/24/2012	NEW	$654,145
														Subtotal = $654,145

Grand Total All Awards = $3,242,368

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3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

Award Number: R01CA160850

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2012

PERIOD OF PERFORMANCE END DATE: 12/31/2017

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