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Obesogenic environment: impact on breast, colorectal, and prostate cancer risk

Award Number: R01CA154644
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2011
PERIOD OF PERFORMANCE END DATE: 08/31/2015

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Obesogenic environment: impact on breast, colorectal, and prostate cancer risk - DESCRIPTION (provided by applicant): The obesogenic environment characterized by man-made or modifiable aspects of an individual's surroundings such as access to food sources, physical activity venues, and physical features affecting obesity, represents an understudied area in cancer research with significant potential to reduce the burden of cancer through approaches that improve opportunities within the environment for healthy eating and physical activity. The goal of this proposal is to understand the effects of neighborhood-level obesogenic factors on risks of breast, colorectal, and prostate cancer with careful consideration of individual-level health behaviors and genetic predisposition among African Americans and Latinos. We propose in Aim 1 to quantify the independent and joint effects of neighborhood-level and individual-level obesity-related factors on breast, colorectal, and prostate cancer risk among African Americans and Latinos of the Multiethnic Cohort Study. We will link prospectively collected individual-level data from 82,545 African Americans and Latinos to geocoded census and geographic information systems data to obtain neighborhood-level data on obesogenic factors. Next, we will test the association between baseline neighborhood-level and individual-level obesogenic factors and incidence of breast, colorectal, and prostate cancers. The Multiethnic Cohort constitutes a well-characterized resource, having follow-up information that spans up to 17 years since its inception in 1993. In Aim 2 we will examine the independent and joint effects of change in neighborhood-level obesogenic factors over time and residential moves on breast, colorectal, and prostate cancer risk among African Americans and Latinos. We will focus on neighborhood-level obesogenic factors that change from baseline (i.e. same individual address with neighborhood changes due to redevelopment/neglect) and purposeful residential moves (i.e. change in address) in a prospective analysis of cancer risk. Our final Aim 3 will examine heterogeneity in neighborhood- level obesogenic effects by known obesity, body mass index, and cancer susceptibility loci among African Americans and Latinos. This aim will capitalize on existing genotype data for these variants from our nested case-control studies of breast cancer (cases/controls=1239/1603), colorectal cancer (cases/controls=675/1225), and prostate cancer (cases/controls=2275/2275) among African Americans and Latinos. The strengths of this proposal include: 1) the innovativeness of the research; 2) the multi-disciplinary investigative team, 3) the efficient use of existing resources, and 4) the scientific and public health significance, especially in regards to understudied minority populations. The knowledge gained by this study may lead to important insight into the multilevel pathways of breast, colorectal, and prostate cancer development, and applying this information may improve the prevention of these common cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	5	2/17/2017	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $38,297 )
2015	2015	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	5	6/5/2015	SUPPLEMENT FOR EXPANSION	$38,297
														Subtotal = $38,297

Issue Date FY: 2014 ( Subtotal = $334,144 )
2014	2014	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	5	8/6/2014	NON-COMPETING CONTINUATION	$334,144
														Subtotal = $334,144

Issue Date FY: 2013 ( Subtotal = $338,321 )
2013	2013	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	002	4	8/28/2013	NON-COMPETING CONTINUATION	$338,321
2013	2012	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	001	3	8/9/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$322,233
2013	2012	UNIVERSITY OF HAWAII	2530 Dole St., Sakamaki D200	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	2	8/9/2013	NON-COMPETING CONTINUATION	-$322,233
														Subtotal = $338,321

Issue Date FY: 2012 ( Subtotal = $322,234 )
2012	2012	UNIVERSITY OF HAWAII	2530 Dole St., Sakamaki D200	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	2	9/7/2012	NON-COMPETING CONTINUATION	$322,234
														Subtotal = $322,234

Issue Date FY: 2011 ( Subtotal = $344,827 )
2011	2011	UNIVERSITY OF HAWAII	2530 Dole St., Sakamaki D200	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	1	9/1/2011	NEW	$344,827
														Subtotal = $344,827

Grand Total All Awards = $1,377,823

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Obesogenic environment: impact on breast, colorectal, and prostate cancer risk

Award Number: R01CA154644

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2011

PERIOD OF PERFORMANCE END DATE: 08/31/2015

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