Tuesday, November 4, 2025 11/4/2025

Systems of Support (SOS) to Increase Colon Cancer Screening and Follow-up

Award Number: R01CA121125
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2007
PERIOD OF PERFORMANCE END DATE: 06/30/2019

Group Awards By:

View Award Description

Systems of Support (SOS) to Increase Colon Cancer Screening and Follow-up - DESCRIPTION (provided by applicant): The lifetime risk of colorectal cancer is over 5% in the United States where, despite recent declines in incidence and mortality, colorectal cancer remains the second highest cause of cancer death. Better treatments have improved survival rates, but morbidity and mortality could be more rapidly and cost-effectively reduced by achieving higher uptake and long-term adherence to colorectal cancer screening. The Systems of Support to Decrease Colorectal Cancer (SOS) study successfully advanced colorectal screening. SOS was a 4-arm randomized controlled trial that leveraged electronic health record data and automated systems to implement stepwise increases in screening support. Patients due for screening (n=4675) were randomized to (1) Usual Care, (2) Automated care (automated mailings and fecal occult blood tests), (3) automated plus assisted care from medical assistants (phone reminders and sending orders to physicians to sign), or (4) automated + assisted + navigated care from registered nurses (follow-up until test completion). Interventions were repeated in year 2. Compared to usual care, intervention patients were more likely to be current for colorectal cancer screening in both study years, with increases by intervention intensity: Usual Care 26.5%, Automated 50.7%, Assisted 57.7%, and Navigated 64.4% (P<.001). We propose to improve and continue SOS interventions up to 10 years and measure their effects on long-term adherence and outcomes. We will: 1. Identify factors related to low or non-adherence to screening despite receiving continued interventions and apply these findings to a stepped intervention to increase uptake and long-term adherence of screening. 2. Assess the effectiveness of the SOS interventions on long-term screening adherence up to 10 years. 3. Describe the impact of SOS interventions on colorectal cancer-related costs and clinical outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$83 )
2021	2016	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	601 UNION ST STE 3100	SEATTLE	WA	98101	KING	USA	Cancer Cause and Prevention Research	000	9	6/21/2021	EXTENSION WITH OR WITHOUT FUNDS	-$83
														Subtotal = -$83

Issue Date FY: 2020 ( Subtotal = -$9,572 )
2020	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Cancer Cause and Prevention Research	000	10	12/13/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$9,572
														Subtotal = -$9,572

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Cancer Cause and Prevention Research	001	10	1/11/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$298,155
2018	2016	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	601 UNION ST STE 3100	SEATTLE	WA	98101	KING	USA	Cancer Cause and Prevention Research	000	9	1/11/2018	EXTENSION WITH OR WITHOUT FUNDS	-$298,155
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $639,706 )
2017	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Cancer Cause and Prevention Research	002	10	6/21/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$639,706
2017	2016	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	601 UNION ST STE 3100	SEATTLE	WA	98101	KING	USA	Cancer Cause and Prevention Research	001	9	12/5/2016	EXTENSION WITH OR WITHOUT FUNDS	$219,732
2017	2015	KAISER FOUNDATION HEALTH PLAN OF WASHINGTON	601 UNION ST STE 3100	SEATTLE	WA	98101	KING	USA	Cancer Cause and Prevention Research	000	8	12/5/2016	NON-COMPETING CONTINUATION	-$219,732
														Subtotal = $639,706

Issue Date FY: 2016 ( Subtotal = $824,480 )
2016	2016	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	9	6/20/2016	EXTENSION WITH OR WITHOUT FUNDS	$674,835
2016	2016	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	001	9	9/1/2016	EXTENSION WITH OR WITHOUT FUNDS	$149,645
														Subtotal = $824,480

Issue Date FY: 2015 ( Subtotal = $666,696 )
2015	2015	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	8	6/22/2015	NON-COMPETING CONTINUATION	$666,696
														Subtotal = $666,696

Issue Date FY: 2014 ( Subtotal = $644,734 )
2014	2014	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	7	6/13/2014	NON-COMPETING CONTINUATION	$644,734
														Subtotal = $644,734

Issue Date FY: 2013 ( Subtotal = $721,506 )
2013	2013	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	004	6	7/23/2013	COMPETING CONTINUATION	$721,506
2013	2012	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	002	5	7/18/2013	SUPPLEMENT FOR EXPANSION	$0
2013	2011	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	5	6/7/2013	NON-COMPETING CONTINUATION	$0
2013	2011	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	003	5	7/18/2013	NON-COMPETING CONTINUATION	$0
2013	2011	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	001	5	7/18/2013	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $721,506

Issue Date FY: 2012 ( Subtotal = $372,860 )
2012	2012	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	001	5	6/20/2012	SUPPLEMENT FOR EXPANSION	$372,860
2012	2011	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	5	5/30/2012	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $372,860

Issue Date FY: 2011 ( Subtotal = $783,772 )
2011	2011	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	001	5	5/17/2011	NON-COMPETING CONTINUATION	$23,252
2011	2011	GROUP HEALTH COOPERATIVE CENTRAL HOSPITAL	201 16TH AVENUE, EAST	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	002	5	6/28/2011	SUPPLEMENT FOR EXPANSION	$259,253
2011	2011	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	5	4/20/2011	NON-COMPETING CONTINUATION	$501,267
														Subtotal = $783,772

Issue Date FY: 2010 ( Subtotal = $619,337 )
2010	2010	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	4	5/28/2010	NON-COMPETING CONTINUATION	$619,337
														Subtotal = $619,337

Issue Date FY: 2009 ( Subtotal = $1,191,975 )
2009	2009	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	3	5/1/2009	NON-COMPETING CONTINUATION	$725,899
2009	2009	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Trans-NIH Recovery Act Research Support	001	3	8/28/2009	SUPPLEMENT FOR EXPANSION	$466,076
														Subtotal = $1,191,975

Issue Date FY: 2008 ( Subtotal = $879,923 )
2008	2008	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	2	5/13/2008	NON-COMPETING CONTINUATION	$879,923
														Subtotal = $879,923

Issue Date FY: 2007 ( Subtotal = $610,062 )
2007	2007	GROUP HEALTH CO-OPERATIVE OF PUGET SOUND	200 15TH AVENUE SOUTH	SEATTLE	WA	98112	KING	USA	Cancer Cause and Prevention Research	000	1	6/29/2007	NEW	$610,062
														Subtotal = $610,062

Grand Total All Awards = $7,945,396

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Systems of Support (SOS) to Increase Colon Cancer Screening and Follow-up

Award Number: R01CA121125

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2007

PERIOD OF PERFORMANCE END DATE: 06/30/2019

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer