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Sensitivity of multiple myeloma cells to mTOR inhibitors

Award Number: R01CA111448
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2005
PERIOD OF PERFORMANCE END DATE: 04/30/2018

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Sensitivity of multiple myeloma cells to mTOR inhibitors - DESCRIPTION (provided by applicant): PROJECT SUMMARY/ASBTRACT The main objective of this project is to provide a rationale for future therapeutic targeting of the TORC2 multiprotein complex in patients with multiple myeloma. The aims include studying mTOR kinase inhibitors against myeloma cell lines and patient primary cell specimens in vitro and in murine models in vivo, identifying the key TORC2 substrates that are the critical targets for inhibition and testing the role of DEPTOR protein expression in regulating the sensitivity of myeloma cells to TORC2 inhibitors. The viability versus death of myeloma cells as well as their ability to adhere and migrate in vitro will be studied. The identification and development of novel compounds which prevent protein-protein interactions within the TORC2 complex will also be attempted.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC.	11301 WILLSHIRE BLVD BLDG 114 RM 218	LOS ANGELES	CA	90073	LOS ANGELES	USA	Cancer Treatment Research	000	10	7/31/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $184,270 )
2016	2016	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	10	4/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$184,270
														Subtotal = $184,270

Issue Date FY: 2015 ( Subtotal = $184,270 )
2015	2015	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	9	5/1/2015	NON-COMPETING CONTINUATION	$184,270
														Subtotal = $184,270

Issue Date FY: 2014 ( Subtotal = $178,742 )
2014	2014	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	8	5/30/2014	NON-COMPETING CONTINUATION	$178,742
														Subtotal = $178,742

Issue Date FY: 2013 ( Subtotal = $173,214 )
2013	2013	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	7	5/1/2013	NON-COMPETING CONTINUATION	$43,303
2013	2013	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	001	7	6/28/2013	NON-COMPETING CONTINUATION	$129,911
														Subtotal = $173,214

Issue Date FY: 2012 ( Subtotal = $184,270 )
2012	2012	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	6	6/6/2012	COMPETING CONTINUATION	$184,270
														Subtotal = $184,270

Issue Date FY: 2009 ( Subtotal = $188,765 )
2009	2009	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	5	3/18/2009	NON-COMPETING CONTINUATION	$188,765
														Subtotal = $188,765

Issue Date FY: 2008 ( Subtotal = $188,765 )
2008	2008	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	POST OFFICE BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	4	3/20/2008	NON-COMPETING CONTINUATION	$188,765
														Subtotal = $188,765

Issue Date FY: 2007 ( Subtotal = $188,765 )
2007	2007	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	POST OFFICE BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	3	4/13/2007	NON-COMPETING CONTINUATION	$188,765
														Subtotal = $188,765

Issue Date FY: 2006 ( Subtotal = $194,402 )
2006	2006	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	POST OFFICE BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	2	5/31/2006	NON-COMPETING CONTINUATION	$194,402
														Subtotal = $194,402

Issue Date FY: 2005 ( Subtotal = $199,080 )
2005	2005	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	POST OFFICE BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Cancer Treatment Research	000	1	5/24/2005	NEW	$199,080
														Subtotal = $199,080

Grand Total All Awards = $1,864,543

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Sensitivity of multiple myeloma cells to mTOR inhibitors

Award Number: R01CA111448

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2005

PERIOD OF PERFORMANCE END DATE: 04/30/2018

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