Saturday, August 2, 2025 8/2/2025

HIGH-SPEED RELIABLE DETECTION OF CANCER CELLS IN BLOOD

Award Number: R01CA111359
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/06/2006
PERIOD OF PERFORMANCE END DATE: 07/31/2011

Group Awards By:

View Award Description

HIGH-SPEED RELIABLE DETECTION OF CANCER CELLS IN BLOOD - DESCRIPTION (provided by applicant): The medical value of detecting circulating tumor cells (CTCs) in peripheral blood is now established, and a specific approach has FDA approval for managing metastatic patients. While the value is clear, it is also limited in application. For example, the reported results are uninformative for a large percentage of metastatic patients, and no validation exists for earlier stages. The cancer bioengineering research partnership (CBRP) proposes to develop a technology for CTC detection that overcomes these limitations. We will develop a new instrument, the Fiber Array Scan Technology (FAST) cytometer that efficiently scans the large numbers of cells required to detect CTCs and a cell preparation protocol that is optimized for cell retention. We will use these developments to investigate whether more metastatic patients have CTCs than current approaches indicate. We will also investigate the medical efficacy of CTC detection in early stage cancer patients. In addition we will investigate applications for staging at diagnosis, as well as for longitudinal therapy monitoring and long-term patient management. The effort integrates clinical oncology with biophysical analysis methods and opto-mechanical engineering. The CBRP will develop a rare cell detection system that can analyze approximately 50 million cells in 2 minutes with a sensitivity of 10% false negatives and a false positive ratio of less than 1 in 107. The Lead Investigators of the CBRP have developed the initial proof of concept through a multidisciplinary approach bridging optical design, statistical software analysis, experimental medicine, oncology, and pathology at the leading institutions, the Palo Alto Research Center (PARC) and The Scripps Research Institute (TSRI), as well as at the participating institutions, Scripps Clinic and the Scripps Cancer Center. The lead investigators are Richard Bruce, Ph.D. (PARC), who is the principal investigator and will in addition lead the optical and system engineering efforts; Peter Kuhn, Ph.D. (TSRI), who will lead the experimental processing; and Jorge Nieva, MD (TSRI and Scripps Cancer Center), who will lead the oncology and pathology of the CBRP. The lead investigators are experts in their respective fields and provide the required expertise for the multi-disciplinary research program of the CBRP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $704,912 )
2010	2010	PALO ALTO RESEARCH CENTER	3333 COYOTE HILL ROAD	PALO ALTO	CA	94304	SANTA CLARA	USA	Cancer Detection and Diagnosis Research	000	5	8/19/2010	NON-COMPETING CONTINUATION	$704,912
														Subtotal = $704,912

Issue Date FY: 2009 ( Subtotal = $1,445,037 )
2009	2009	PALO ALTO RESEARCH CENTER	3333 COYOTE HILL ROAD	PALO ALTO	CA	94304	SANTA CLARA	USA	Cancer Detection and Diagnosis Research	000	4	7/14/2009	NON-COMPETING CONTINUATION	$777,234
2009	2009	PALO ALTO RESEARCH CENTER	3333 COYOTE HILL ROAD	PALO ALTO	CA	94304	SANTA CLARA	USA	Trans-NIH Recovery Act Research Support	001	4	9/15/2009	SUPPLEMENT FOR EXPANSION	$667,803
														Subtotal = $1,445,037

Issue Date FY: 2008 ( Subtotal = $846,674 )
2008	2008	PALO ALTO RESEARCH CENTER	3333 COYOTE HILL ROAD	PALO ALTO	CA	94304	SANTA CLARA	USA	Cancer Detection and Diagnosis Research	000	3	6/17/2008	NON-COMPETING CONTINUATION	$846,674
														Subtotal = $846,674

Issue Date FY: 2007 ( Subtotal = $911,090 )
2007	2007	PALO ALTO RESEARCH CENTER	3333 COYOTE HILL ROAD	PALO ALTO	CA	94304	SANTA CLARA	USA	Cancer Detection and Diagnosis Research	000	2	7/24/2007	NON-COMPETING CONTINUATION	$911,090
														Subtotal = $911,090

Issue Date FY: 2006 ( Subtotal = $963,509 )
2006	2006	PALO ALTO RESEARCH CENTER	3333 COYOTE HILL ROAD	PALO ALTO	CA	94304	SANTA CLARA	USA	Cancer Detection and Diagnosis Research	000	1	9/6/2006	NEW	$963,509
														Subtotal = $963,509

Grand Total All Awards = $4,871,222

Top

All Categories

About

Search

Reports

Data Submission

Award Information

HIGH-SPEED RELIABLE DETECTION OF CANCER CELLS IN BLOOD

Award Number: R01CA111359

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/06/2006

PERIOD OF PERFORMANCE END DATE: 07/31/2011

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer