Saturday, June 28, 2025 6/28/2025

THE ROLE OF METHYLATION IN P53-DEPENDENT TRANSCRIPTIONAL REGULATION

Award Number: R01CA107549
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2005
PERIOD OF PERFORMANCE END DATE: 02/28/2010

Group Awards By:

View Award Description

THE ROLE OF METHYLATION IN P53-DEPENDENT TRANSCRIPTIONAL REGULATION - DESCRIPTION (provided by applicant): The p53 tumor suppressor protein is a sequence-specific transcription factor that modulates the response of cells to genotoxic stress, including DMA damage. The loss of p53 is associated with development of more than one-half of all human tumors. Upon activation, p53 undergoes massive post-translational modifications that ultimately regulate its biological function. Most of the post-translational modifications are commonly found both in p53 and histones. We have demonstrated previously that acetylation of p53 stimulates recruitment of CBP to the target promoters resulting in acetylation of histones and activation of transcription. We are proposing that methylation, another known posttranslational modification found in histones, is also important for regulation of the p53 function. The overall hypothesis of this proposal is that methylation regulates transcription of p53-dependent genes at multiple levels. The specific questions (aims) that we will address in this proposal are: 1) Does Set9 function as a histone- and/or p53-specific methyltransferase for transcriptional coactivation of the p53-dependent genes in vivo? 2) Is p53 methylated in vivo and what is the functional significance of this modification? Our research design will probe the methylation state of nucleosomes and p53 in vivo and utilize in vivo assays of p53 function to elucidate the role of this modification. The long term goal of our studies are to elucidate the role of post-translational modifications of p53 and chromatin in respect to the transcriptional and tumor suppressor function of p53.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $182,022 )
2009	2009	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER				GBR	Cancer Biology Research	003	6	3/24/2009	NON-COMPETING CONTINUATION	$18,202
2009	2009	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER				GBR	Cancer Biology Research	002	6	3/2/2009	NON-COMPETING CONTINUATION	$163,820
2009	2008	NEW ENGLAND MEDICAL CENTER HOSPITALS, INC	750 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Cancer Biology Research	000	4	10/24/2008	NON-COMPETING CONTINUATION	-$117,222
2009	2008	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER				GBR	Cancer Biology Research	001	5	10/24/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$117,222
														Subtotal = $182,022

Issue Date FY: 2008 ( Subtotal = $274,719 )
2008	2008	TUFTS MEDICAL CENTER	800 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Cancer Biology Research	000	4	2/26/2008	NON-COMPETING CONTINUATION	$274,719
														Subtotal = $274,719

Issue Date FY: 2007 ( Subtotal = $274,719 )
2007	2007	NEW ENGLAND MEDICAL CENTER HOSPITALS, INC	750 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Cancer Biology Research	000	3	2/1/2007	NON-COMPETING CONTINUATION	$274,719
														Subtotal = $274,719

Issue Date FY: 2006 ( Subtotal = $282,924 )
2006	2006	NEW ENGLAND MEDICAL CENTER HOSPITALS, INC	750 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Cancer Biology Research	000	2	3/24/2006	NON-COMPETING CONTINUATION	$282,924
														Subtotal = $282,924

Issue Date FY: 2005 ( Subtotal = $289,733 )
2005	2005	NEW ENGLAND MEDICAL CENTER HOSPITALS, INC	750 WASHINGTON STREET	BOSTON	MA	02111	SUFFOLK	USA	Cancer Biology Research	000	1	3/31/2005	NEW	$289,733
														Subtotal = $289,733

Grand Total All Awards = $1,304,117

Top

All Categories

About

Search

Reports

Data Submission

Award Information

THE ROLE OF METHYLATION IN P53-DEPENDENT TRANSCRIPTIONAL REGULATION

Award Number: R01CA107549

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2005

PERIOD OF PERFORMANCE END DATE: 02/28/2010

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer