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DIET AND BREAST DENSITY OVER TIME IN US CHINESE WOMEN

Award Number: R01CA106606
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2005
PERIOD OF PERFORMANCE END DATE: 06/30/2013

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DIET AND BREAST DENSITY OVER TIME IN US CHINESE WOMEN - Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur over time in foreign-born Chinese American women, such as changes in diet, could contribute to our understanding of how acculturative changes, particularly in adulthood, affect breast cancer risk. Breast density represents an especially useful marker of risk because of its strong association with breast cancer, and because change in breast density over time may reflect the effects of recent behaviors and exposures. The objectives of the proposed study are to characterize for the first time changes in diet and breast density over time in first-generation Chinese American women, and to examine dietary and other correlates of change in breast density. We will recruit 420 pre- or peri-menopausal Chinese American women of screening mammography age with US residence <=7 years. Data collection will include baseline questionnaires on dietary intake, acculturation, and health and reproductive histories; 4-day dietary recalls; anthropometric measures; serum insulin-like growth factor-l level; and a screening mammogram assessed for breast density. Two follow-up measures of the same factors will be obtained at 12- to 24-month intervals. Changes in diet, other behavioral factors, and breast density will be described, as well as dietary and other correlates of breast density change. The research team and the presence of a sizable Chinese American community in the Philadelphia area offer a first opportunity to examine changes in diet and breast density over time in a unique sample of first-generation Chinese American women. Findings will address the extent to which acculturation-related lifestyle changes contribute to the transition in breast cancer risk experienced by Chinese American women. They will also address the issue of modifiability of breast cancer risk in women regardless of ethnicity by examining changes in risk factors during adulthood and by identifying the specific factors of greatest importance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	5	12/27/2012	NON-COMPETING CONTINUATION	$0
2013	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	5	12/27/2012	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	5	6/20/2011	SUPPLEMENT FOR EXPANSION	$0
2011	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	5	6/16/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $7,294 )
2010	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	5	11/19/2009	SUPPLEMENT FOR EXPANSION	$0
2010	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	002	5	11/19/2009	NON-COMPETING CONTINUATION	$7,294
2010	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	001	5	11/19/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,294

Issue Date FY: 2009 ( Subtotal = $812,483 )
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	004	5	7/14/2009	SUPPLEMENT FOR EXPANSION	$302,976
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	003	5	9/15/2009	NON-COMPETING CONTINUATION	$7,294
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	4	3/17/2009	SUPPLEMENT FOR EXPANSION	$67,009
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	4	8/3/2009	SUPPLEMENT FOR EXPANSION	-$288
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	002	5	6/18/2009	NON-COMPETING CONTINUATION	$435,492
														Subtotal = $812,483

Issue Date FY: 2008 ( Subtotal = $497,251 )
2008	2008	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	4	6/11/2008	NON-COMPETING CONTINUATION	$497,251
														Subtotal = $497,251

Issue Date FY: 2007 ( Subtotal = $507,702 )
2007	2007	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	3	6/12/2007	NON-COMPETING CONTINUATION	$507,702
														Subtotal = $507,702

Issue Date FY: 2006 ( Subtotal = $465,455 )
2006	2006	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	6/16/2006	NON-COMPETING CONTINUATION	$465,455
														Subtotal = $465,455

Issue Date FY: 2005 ( Subtotal = $527,647 )
2005	2005	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	1	8/29/2005	NEW	$527,647
														Subtotal = $527,647

Grand Total All Awards = $2,817,832

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DIET AND BREAST DENSITY OVER TIME IN US CHINESE WOMEN

Award Number: R01CA106606

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2005

PERIOD OF PERFORMANCE END DATE: 06/30/2013

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