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Advanced Ultrasonic Evaluation of Sentinel Lymph Nodes

Award Number: R01CA100183
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2006
PERIOD OF PERFORMANCE END DATE: 07/31/2017

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Advanced Ultrasonic Evaluation of Sentinel Lymph Nodes - DESCRIPTION (provided by applicant): Riverside Research Institute, the University of Hawaii and Kuakini Medical Center, and the National Center for Scientific Research (Paris, France) propose to continue to investigate, refine, and expand the use of novel quantitative ultrasound methods for discriminating between cancer-containing and cancer-free lymph nodes of cancer patients. Detection of metastatic cancer in lymph nodes is absolutely crucial for accurate staging, prognosis, and treatment planning. Our overall objective is to reduce markedly the unacceptable failure of existing histopathological methods to detect metastases in 25% to 30% of dissected nodes and 50% in nodes with micrometastases. To achieve this objective, we proposed to develop quantitative imaging methods using high-frequency ultrasound in the pathology laboratory to identify regions of dissected nodes that warrant careful histologic examination. We have made exciting progress toward this objective by developing a sensitive and specific ultrasonic method of imaging metastatic disease present in lymph nodes with fine spatial resolution. Our results have shown a remarkable ability to detect cancer in dissected lymph nodes for a broad range of cancer types, and they promise a revolutionary means of guiding pathologists to cancer-containing regions of dissected lymph nodes. The demonstrated ability of our proposed methods to pinpoint metastatic cancer potentially can reduce the occurrence of false-negative determinations drastically when nodes contain micrometastatic disease, which easily can be overlooked using current histopathology methods. Our current results substantially have validated our original hypothesis that the proposed methods can identify cancer- containing regions of dissected nodes with a simultaneous sensitivity and specificity of approximately 90%. These findings provide encouragement that our proposed studies fully achieve our general objective, and they suggest that a simultaneous sensitivity and specificity exceeding 95% in fact may be possible. Therefore, we propose to acquire additional data to expand our existing database and thoroughly validate our findings. We also propose to investigate the feasibility of applying the same techniques at lower frequencies for clinical use in the examination or operating room to identify nodes that warrant biopsy or dissection. In addition, we propose to improve models for ultrasound scattering in lymph nodes using very-high-frequency ultrasonic microscopy and to formulate engineering specifications for a low-cost ultrasound instrument capable of performing node evaluations routinely in the pathology laboratory. In conclusion, this project can benefit lymph-node evaluations for staging, prognosis, and treatment planning of all types of cancers, e.g., breast, colorectal, gastric, pancreatic, lung, thyroid, prostate, etc., as well as sentinel-node dissection procedures, e.g., for breast cancer. The methods we are developing clearly can have a significant beneficial impact on in situ evaluations of lymph nodes examined prior to or during surgery, intra-operative evaluations of regional nodes including sentinel-nodes, and post-operative evaluations of dissected nodes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM ST 9TH FL	NEW YORK	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	9	12/7/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $241,653 )
2015	2015	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	9	8/3/2015	NON-COMPETING CONTINUATION	$241,653
														Subtotal = $241,653

Issue Date FY: 2014 ( Subtotal = $234,401 )
2014	2014	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	8	8/1/2014	NON-COMPETING CONTINUATION	$234,401
														Subtotal = $234,401

Issue Date FY: 2013 ( Subtotal = $227,153 )
2013	2013	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	7	7/9/2013	NON-COMPETING CONTINUATION	$227,153
														Subtotal = $227,153

Issue Date FY: 2012 ( Subtotal = $241,652 )
2012	2012	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	6	7/19/2012	NON-COMPETING CONTINUATION	$241,652
														Subtotal = $241,652

Issue Date FY: 2011 ( Subtotal = $240,062 )
2011	2011	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	5	9/22/2011	COMPETING CONTINUATION	$240,062
														Subtotal = $240,062

Issue Date FY: 2009 ( Subtotal = $252,162 )
2009	2009	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	4	7/3/2009	NON-COMPETING CONTINUATION	$252,162
														Subtotal = $252,162

Issue Date FY: 2008 ( Subtotal = $246,304 )
2008	2008	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	3	8/1/2008	NON-COMPETING CONTINUATION	$246,304
														Subtotal = $246,304

Issue Date FY: 2007 ( Subtotal = $253,049 )
2007	2007	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	2	8/23/2007	NON-COMPETING CONTINUATION	$253,049
														Subtotal = $253,049

Issue Date FY: 2006 ( Subtotal = $262,537 )
2006	2006	RIVERSIDE RESEARCH INSTITUTE	156 WILLIAM STREET, NINTH FL	MANHATTAN	NY	10038	NEW YORK	USA	Cancer Detection and Diagnosis Research	000	1	9/19/2006	NEW	$262,537
														Subtotal = $262,537

Grand Total All Awards = $2,198,973

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Advanced Ultrasonic Evaluation of Sentinel Lymph Nodes

Award Number: R01CA100183

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2006

PERIOD OF PERFORMANCE END DATE: 07/31/2017

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