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Mouse Models of Human Cancer Database

Award Number: R01CA089713
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2000
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Mouse Models of Human Cancer Database - PROJECT SUMMARY/ABSTRACT The laboratory mouse is the preeminent animal model system for investigation into the biology and genetics of human cancer. Mouse models have provided key insights into cancer susceptibility, the molecular genetics of tumor suppressor and oncogenes, and therapy response in pre-clinical and co-clinical studies. Human tumors engrafted into immune compromised and humanized mice (aka, Patient Derived Xenografts) are playing an increasingly important role as a powerful preclinical platform for testing new cancer treatments. The Mouse Models of Human Cancer (MMHC) database is a unique on-line compendium of mouse models for human cancer. MMHCdb provides electronic access to expertly curated and harmonized information on diverse mouse models for human cancer along with tools for accessing and visualizing associated data from these models. This in turn, facilitates the selection of appropriate strains of mice for cancer genetics research. MMHCdb integrates data derived from peer-reviewed literature and from direct submissions from researchers. Data in MMHCdb are also obtained from other bioinformatics resources including PathBase, HUGO Human Gene Nomenclature database, the Gene Expression Omnibus (GEO), and ArrayExpress. In this proposal we describe our plans for the continued development of MMHCdb with an emphasis on expanded support for analysis of tumor genomic data and drug response data from Patient Derived Xenograft models. To accomplish these goals we will build on successful collaborations to develop data standards for PDX models that are now widely adopted. The major goals for the project renewal include the following: · continue to populate MMHCdb with data on strain-specific patterns of tumorigenesis in inbred, mutant, and genetically engineered mice, · leverage collaborations with Seven Bridges and PDXNet to analyze genomic data for PDX models using a common analysis pipeline, · develop a platform for the analysis of PDX genomic and drug response data, and · support the infrastructure of MMHCdb and our user community through ongoing database maintenance, development of new software components, user support services, and community outreach activities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $790,662 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	22	6/7/2024	NON-COMPETING CONTINUATION	$790,662
														Subtotal = $790,662

Issue Date FY: 2023 ( Subtotal = $812,369 )
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	21	5/25/2023	NON-COMPETING CONTINUATION	$796,122
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	21	9/15/2023	NON-COMPETING CONTINUATION	$16,247
														Subtotal = $812,369

Issue Date FY: 2022 ( Subtotal = $720,266 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	002	20	6/28/2022	NON-COMPETING CONTINUATION	$720,266
2022	2021	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	19	10/19/2021	COMPETING CONTINUATION	$227
2022	2020	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	18	10/19/2021	NON-COMPETING CONTINUATION	-$227
														Subtotal = $720,266

Issue Date FY: 2021 ( Subtotal = $756,430 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	19	7/2/2021	COMPETING CONTINUATION	$756,430
2021	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	18	6/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $756,430

Issue Date FY: 2020 ( Subtotal = $778,386 )
2020	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	18	4/15/2020	NON-COMPETING CONTINUATION	$778,386
														Subtotal = $778,386

Issue Date FY: 2019 ( Subtotal = $755,036 )
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	17	4/16/2019	NON-COMPETING CONTINUATION	$755,036
														Subtotal = $755,036

Issue Date FY: 2018 ( Subtotal = $788,333 )
2018	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	16	7/6/2018	NON-COMPETING CONTINUATION	$788,333
														Subtotal = $788,333

Issue Date FY: 2017 ( Subtotal = $788,333 )
2017	2017	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	15	7/5/2017	NON-COMPETING CONTINUATION	$788,333
														Subtotal = $788,333

Issue Date FY: 2016 ( Subtotal = $784,347 )
2016	2016	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	14	4/19/2016	COMPETING CONTINUATION	$784,347
														Subtotal = $784,347

Issue Date FY: 2014 ( Subtotal = $747,270 )
2014	2014	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	13	4/25/2014	NON-COMPETING CONTINUATION	$747,270
														Subtotal = $747,270

Issue Date FY: 2013 ( Subtotal = $733,286 )
2013	2013	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	12	5/2/2013	NON-COMPETING CONTINUATION	$183,321
2013	2013	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	12	6/25/2013	NON-COMPETING CONTINUATION	$549,965
														Subtotal = $733,286

Issue Date FY: 2012 ( Subtotal = $793,294 )
2012	2012	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	11	4/16/2012	NON-COMPETING CONTINUATION	$793,294
														Subtotal = $793,294

Issue Date FY: 2011 ( Subtotal = $794,817 )
2011	2011	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	10	5/17/2011	NON-COMPETING CONTINUATION	$35,234
2011	2011	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	10	4/18/2011	NON-COMPETING CONTINUATION	$759,583
														Subtotal = $794,817

Issue Date FY: 2010 ( Subtotal = $813,549 )
2010	2010	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	9	6/14/2010	COMPETING CONTINUATION	$813,549
2010	2010	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	002	9	6/22/2010	COMPETING CONTINUATION	$0
2010	2009	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	8	6/10/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $813,549

Issue Date FY: 2009 ( Subtotal = $749,560 )
2009	2009	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	8	11/7/2008	NON-COMPETING CONTINUATION	$674,604
2009	2009	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	001	8	3/18/2009	NON-COMPETING CONTINUATION	$74,956
														Subtotal = $749,560

Issue Date FY: 2008 ( Subtotal = $738,187 )
2008	2008	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	7	12/5/2007	NON-COMPETING CONTINUATION	$738,187
														Subtotal = $738,187

Issue Date FY: 2007 ( Subtotal = $733,582 )
2007	2007	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	6	1/31/2007	NON-COMPETING CONTINUATION	$733,582
														Subtotal = $733,582

Issue Date FY: 2006 ( Subtotal = $732,795 )
2006	2006	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	5	2/20/2006	COMPETING CONTINUATION	$732,795
														Subtotal = $732,795

Issue Date FY: 2005 ( Subtotal = $732,162 )
2005	2005	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	4	1/11/2005	NON-COMPETING CONTINUATION	$732,162
														Subtotal = $732,162

Issue Date FY: 2004 ( Subtotal = $719,736 )
2004	2004	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Cancer Biology Research	000	3	12/9/2003	NON-COMPETING CONTINUATION	$719,736
														Subtotal = $719,736

Issue Date FY: 2003 ( Subtotal = $696,092 ) (Continued on the next page)
Grand Total All Awards = $16,669,695

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Mouse Models of Human Cancer Database

Award Number: R01CA089713

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2000

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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