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RAMAN SPECTROSCOPY FOR CANCER DIAGNOSIS AND MONITORING

Award Number: R01CA089255
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/08/2001
PERIOD OF PERFORMANCE END DATE: 02/28/2006

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RAMAN SPECTROSCOPY FOR CANCER DIAGNOSIS AND MONITORING - DESCRIPTION (Verbatim from Applicant's Abstract): Our general objective is to enable the application of vibrational spectroscopy to cancer diagnosis and treatment monitoring. The detection of cancer at its earliest stages is crucial, for it greatly improves the likelihood of successful treatment. Traditional methods of diagnosis have relied on physical removal of a portion of tissue and microscopic assessment of morphology. The need for tissue removal reduces the area of tissue that can be sampled. A noninvasive technique would eliminate this problem. Furthermore, a noninvasive technique has the potential to allow treatment to begin during the same endoscopic procedure used for diagnosis and reduce other complications associated with tissue removal such as tissue handling and increased risk of infection to the patient. We will focus on developing Raman spectroscopy for detection of precancerous conditions in patients with Barrett's esophagus. Barrett's esophagus is a pathology in which the squamous epithelial lining is replaced by a specialized metaplastic epithelium and the likelihood of adenocarcinoma is increased. Because the microscopic changes of dysplasia are difficult to observe, the entire area of metaplastic epithelium should be sampled. Therefore, Barrett's esophagus is well-suited for a noninvasive diagnostic technique. The methods and techniques developed in this proposal may also find application in other tissues such as the cervix. The second goal of our work is to develop Raman spectroscopy as a method for assessing the effects of treatment. Current methods for monitoring the response of an individual tumor to therapy are unreliable and often difficult to implement during the course of therapy. Development of noninvasive or minimally-invasive optical methods to reliably identify regions of apoptosis and necrosis would provide a simple method for assaying tumor response in each individual cancer patient. Consequently, treatments could be customized.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $801,672 )
2005	2005	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Cancer Treatment Research	000	5	8/24/2005	NON-COMPETING CONTINUATION	$801,672
														Subtotal = $801,672

Issue Date FY: 2004 ( Subtotal = $821,649 )
2004	2004	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Cancer Treatment Research	000	4	2/13/2004	NON-COMPETING CONTINUATION	$821,649
														Subtotal = $821,649

Issue Date FY: 2003 ( Subtotal = $707,975 )
2003	2003	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Cancer Treatment Research	000	3		NON-COMPETING CONTINUATION	$707,975
														Subtotal = $707,975

Issue Date FY: 2002 ( Subtotal = $522,852 )
2002	2002	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Cancer Treatment Research	000	2	3/5/2002	NON-COMPETING CONTINUATION	$522,852
														Subtotal = $522,852

Issue Date FY: 2001 ( Subtotal = $559,624 )
2001	2001	UNIVERSITY OF CALIFORNIA, LOS ALAMOS NAT'L LABORATORY	POST OFFICE BOX 1663	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Cancer Detection and Diagnosis Research	000	1	5/8/2001	NEW	$559,624
														Subtotal = $559,624

Grand Total All Awards = $3,413,772

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RAMAN SPECTROSCOPY FOR CANCER DIAGNOSIS AND MONITORING

Award Number: R01CA089255

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/08/2001

PERIOD OF PERFORMANCE END DATE: 02/28/2006

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