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Functional Analysis of Rad23 Protein

Award Number: R01CA083875
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2000
PERIOD OF PERFORMANCE END DATE: 07/31/2017

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Functional Analysis of Rad23 Protein - DESCRIPTION (provided by applicant): Despite significant advances in understanding the biochemical basis of nucleotide excision repair (NER), there is no cure for individuals with Xeroderma pigmentosum, Cockayne Syndrome, Fanconi Anemia, and other DNA repair defects. Current therapy is focused on relieving symptoms and improving quality of life. The ubiquitin/proteasome system (UPS) of interacellular protein degradation has been extensively studied, and is implicated in cell cycle control, stress response, signal transduction, and DNA repair. We determined that the NER protein Rad4 is highly unstable, and is rapidly degraded by the proteasome. Remarkably, a number of additional DNA repair proteins have protein degradation functions, including Rad6, Rad7, Rad16 and FANCL. My laboratory has, for the past 15 years, investigated the role of protein degradation in DNA repair. We determined that Rad4 is stabilized when it forms a complex with the DNA repair factor, Rad23. Rad23 can also bind the proteasome and deliver ubiquitinated substrates. We recently discovered that the localization of proteasomes at the nuclear periphery is required for DNA repair. The studies proposed here will use genetic, biochemical and cell biological approaches to investigate the role of the UPS in nucleotide excision repair. We will characterize the proteins that traffic proteasomes, and determine how nuclear substrates, including Rad4, are targeted to the proteasome. These mechanistic studies are expected to have a broad impact, as they will show that proteasome trafficking represents a previously unknown regulatory process in intracellular protein degradation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$1,209 )
2019	2016	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	16	1/18/2019	EXTENSION WITH OR WITHOUT FUNDS	-$1,209
														Subtotal = -$1,209

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	16	3/21/2017	EXTENSION WITH OR WITHOUT FUNDS	$28,979
2017	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	15	3/21/2017	NON-COMPETING CONTINUATION	-$28,979
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $292,679 )
2016	2016	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	16	8/2/2016	EXTENSION WITH OR WITHOUT FUNDS	$292,679
														Subtotal = $292,679

Issue Date FY: 2015 ( Subtotal = $292,679 )
2015	2015	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	15	7/24/2015	NON-COMPETING CONTINUATION	$292,679
														Subtotal = $292,679

Issue Date FY: 2014 ( Subtotal = $283,899 )
2014	2014	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	002	14	8/19/2014	NON-COMPETING CONTINUATION	$283,899
2014	2012	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	12	1/7/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$17,272
2014	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	11	1/7/2014	COMPETING CONTINUATION	$17,272
														Subtotal = $283,899

Issue Date FY: 2013 ( Subtotal = $275,119 )
2013	2013	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Cancer Cause and Prevention Research	002	13	8/20/2013	NON-COMPETING CONTINUATION	$275,119
2013	2012	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Cancer Cause and Prevention Research	001	12	8/12/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$107,554
2013	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	11	8/12/2013	COMPETING CONTINUATION	-$107,554
														Subtotal = $275,119

Issue Date FY: 2012 ( Subtotal = $285,543 )
2012	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	11	9/6/2012	COMPETING CONTINUATION	$285,543
														Subtotal = $285,543

Issue Date FY: 2010 ( Subtotal = $286,237 )
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	10	12/10/2009	NON-COMPETING CONTINUATION	$257,613
2010	2010	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	10	1/25/2010	NON-COMPETING CONTINUATION	$28,624
														Subtotal = $286,237

Issue Date FY: 2009 ( Subtotal = $286,237 )
2009	2009	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	9	3/19/2009	NON-COMPETING CONTINUATION	$28,624
2009	2009	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	9	12/4/2008	NON-COMPETING CONTINUATION	$257,613
														Subtotal = $286,237

Issue Date FY: 2008 ( Subtotal = $286,237 )
2008	2008	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	8	1/1/2008	NON-COMPETING CONTINUATION	$286,237
														Subtotal = $286,237

Issue Date FY: 2007 ( Subtotal = $286,237 )
2007	2007	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	7	1/8/2007	NON-COMPETING CONTINUATION	$286,237
														Subtotal = $286,237

Issue Date FY: 2006 ( Subtotal = $283,844 )
2006	2006	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	6	2/10/2006	COMPETING CONTINUATION	$283,844
														Subtotal = $283,844

Issue Date FY: 2004 ( Subtotal = $342,044 )
2004	2004	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	5	6/18/2004	NON-COMPETING CONTINUATION	$302,421
2004	2004	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	5	6/23/2004	SUPPLEMENT FOR EXPANSION	$39,623
														Subtotal = $342,044

Issue Date FY: 2003 ( Subtotal = $332,228 )
2003	2003	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	4	5/28/2003	SUPPLEMENT FOR EXPANSION	$38,467
2003	2003	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	4	5/21/2003	NON-COMPETING CONTINUATION	$293,761
														Subtotal = $332,228

Issue Date FY: 2002 ( Subtotal = $285,352 )
2002	2002	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	3	5/20/2002	NON-COMPETING CONTINUATION	$285,352
														Subtotal = $285,352

Issue Date FY: 2001 ( Subtotal = $277,192 )
2001	2001	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	2	6/22/2001	NON-COMPETING CONTINUATION	$277,192
														Subtotal = $277,192

Issue Date FY: 2000 ( Subtotal = $297,625 )
2000	2000	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	1	3/30/2000	NEW	$297,625
														Subtotal = $297,625

Grand Total All Awards = $4,391,943

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Functional Analysis of Rad23 Protein

Award Number: R01CA083875

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2000

PERIOD OF PERFORMANCE END DATE: 07/31/2017

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