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2 & 3D IMAGING OF CONTRAST AGENTS IN ANIMAL MODELS

Award Number: R01CA072895
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/1997
PERIOD OF PERFORMANCE END DATE: 06/30/2005

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2 & 3D IMAGING OF CONTRAST AGENTS IN ANIMAL MODELS - Near Infrared (NIR) optical imaging technologies provide sensitive localization of small heterogeneities deep within the human breast using intrinsic absorption (mua) and scattering (mus'). In order to achieve a further enhancement of the sensitivity and specificity (S/S) of cancer detection by the optical method, we propose to refocus our activity in this competitive renewal application towards extrinsic contrast in cancers in animal models. The proposed work will first determine the Figure of Merit, M, of the extrinsic agents and to quantify the increase in M with NIR contrast agents using both fluorescence and absorbance detection of the very small (20 pmole) amounts of extrinsic probes in animal tumors. Several instrumentation schemes are required for these studies and include: 1) An improved phased array system with localization of indocyanine green (ICG) demonstrated in model systems to 0.2 mm and 9L glioma 20 p moles of ICG is proposed for animal tumors including prostate cancer and human breast cancer detection where S/S can be evaluated in early, small tumors. Two other instruments appropriate to the animal models will be employed. 2) A flying spot scanner of 1 mm resolution for superficial tumors (mouse only) and adapted to imaging the NIR fluorescence signals. 3) a three-dimensional imager with less than 50 micron resolution requiring snap freezing of the tumor will be used to localize contrast agents in all non-human tumors. The latter system is essential to a critical evaluation of the phased array system. Seven NIR contrast agents based upon ICG and including molecular beacons will be compared in animal models using the above mentioned detection methods. Quantitative comparison will be afforded using the Figure of Merit(M) based upon tumor/tissue contrast agent (C), retention time (R)(min), and fluorescence quantum yield ratio (Q). M is calculated on the basis of a linear model (i.e., the product of these three quantities). Thus, an intensive, ambitious quantitative evaluation of currently available contrast agents will afford an animal model data base transfer to human breast tumors using FDA approved ICG (and others later) and phased array localization co-registered with gadolinium chelate tumor MRI images in "bench to bedside" studies (NIH Workshop, September 14-17, 2000).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $244,850 )
2004	2004	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Cancer Detection and Diagnosis Research	000	8	6/25/2004	NON-COMPETING CONTINUATION	$244,850
														Subtotal = $244,850

Issue Date FY: 2003 ( Subtotal = $244,850 )
2003	2003	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION							Cancer Detection and Diagnosis Research	000	7	7/25/2003	NON-COMPETING CONTINUATION	$244,850
														Subtotal = $244,850

Issue Date FY: 2002 ( Subtotal = $244,850 )
2002	2002	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION							Cancer Detection and Diagnosis Research	000	6	8/15/2002	NON-COMPETING CONTINUATION	$244,850
														Subtotal = $244,850

Issue Date FY: 2001 ( Subtotal = $265,600 )
2001	2001	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION							Cancer Detection and Diagnosis Research	000	5	8/1/2001	COMPETING CONTINUATION	$265,600
														Subtotal = $265,600

Issue Date FY: 2000 ( Subtotal = $139,218 )
2000	2000	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Cancer Detection and Diagnosis Research	000	4	5/29/2000	NON-COMPETING CONTINUATION	$139,218
														Subtotal = $139,218

Issue Date FY: 1999 ( Subtotal = $135,165 )
1999	1999	MEDICAL DIAGNOSTIC RESEARCH FOUNDATION	39 NORTHWOODS ROAD	RADNOR	PA	19087	DELAWARE	USA	Cancer Detection and Diagnosis Research	000	3	9/30/1999	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$135,165
														Subtotal = $135,165

Issue Date FY: 1998 ( Subtotal = $129,188 )
1998	1998	UNIVERSITY CITY SCIENCE CENTER	3624 MARKET STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	2	3/19/1998	NON-COMPETING CONTINUATION	$129,188
														Subtotal = $129,188

Grand Total All Awards = $1,403,721

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2 & 3D IMAGING OF CONTRAST AGENTS IN ANIMAL MODELS

Award Number: R01CA072895

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/1997

PERIOD OF PERFORMANCE END DATE: 06/30/2005

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