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CRCNS: Multimodal network interactions for internal state dynamics of resiliency

Award Number: R01AT013189
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/28/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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CRCNS: Multimodal network interactions for internal state dynamics of resiliency - Resiliency to stress is crucial to the health of individuals and of society. While the detrimental effects of prolonged stress are well-documented, there remains a critical knowledge gap regarding the mechanisms underlying individual resilience to adverse outcomes. The circuits underlying stress resiliency, and how resilient individuals tap into these circuits to maintain normal behavioral function, are not fully understood. Furthermore, resiliency occurs over both long and short timescales and likely emerges from interactions across neural subsystems that span molecules to whole-brain connectivity. To unravel these complex mechanisms, we will use a multidisciplinary approach that combines time course experiments, machine learning, signal processing, and statistical inference to integrate multidimensional data from the transcriptome to the whole-brain connectome to characterize how circuit activity gives rise to resiliency. We will collect behavioral, neuroimaging, electrophysiological, gene expression, and biomarker data from well-validated mouse models of resilience. We will also develop new computational tools to characterize the multiscale network dynamics of genes, molecules, and circuits that underlie the neurobiological substrates of resilience. We will validate these relationships in another mouse strain to determine the specificity of our model. This will be the first study to provide a comprehensive understanding of interactions between neural circuits and their molecular, genomic, and neuroanatomical contexts in animal models of resilience. If successful, our findings could yield insights into unifying principles of how neural mechanisms interact to generate behavioral phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $362,715 )
2026	2026	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Research and Training in Complementary and Integrative Health	000	3	7/3/2026	NON-COMPETING CONTINUATION	$362,715
														Subtotal = $362,715

Issue Date FY: 2025 ( Subtotal = $332,454 )
2025	2025	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Research and Training in Complementary and Integrative Health	000	2	6/25/2025	NON-COMPETING CONTINUATION	$332,454
														Subtotal = $332,454

Issue Date FY: 2024 ( Subtotal = $375,873 )
2024	2024	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Research and Training in Complementary and Integrative Health	000	1	8/28/2024	NEW	$375,873
														Subtotal = $375,873

Grand Total All Awards = $1,071,042

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CRCNS: Multimodal network interactions for internal state dynamics of resiliency

Award Number: R01AT013189

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/28/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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