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Neural Circuitry of Motioninduced Nausea

Award Number: R01AT013056
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Neural Circuitry of Motioninduced Nausea - PROJECT SUMMARY Nausea is a queasy sensation that arises from interoception of physiological distress within the body. However, there remains a critical gap in the fundamental understanding of neurons and neural circuits responsible for this debilitating condition. This proposal focuses on motion sickness (originating in the brain) rather than chemically induced nausea (originating in the viscera), thereby providing an innovative, orthogonal view into the cellular and circuit mechanisms of nausea. The overall objective in this application is to understand how motion-induced nausea is elicited in the brain. The central hypothesis posits that specific neurons in the caudal hindbrain are responsible for the sickness. This hypothesis will be tested in mice by addressing the following three specific aims: 1) Establishing the necessity and sufficiency of discrete subsets of hindbrain neurons for motion-induced nausea; 2) Identifying the genetic profile defining hindbrain neurons associated with nausea; and 3) Mapping the presynaptic to and postsynaptic connections from these neurons. The proposed research is significant because it will reveal the molecules, cells, and circuits responsible for motion-induced nausea. The anticipated outcomes of these studies promise unique and powerful inroads into how the mammalian brain processes distress signals from the body and orchestrates responsive measures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $632,278 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research and Training in Complementary and Integrative Health	000	2	6/18/2026	NON-COMPETING CONTINUATION	$632,278
														Subtotal = $632,278

Issue Date FY: 2025 ( Subtotal = $487,726 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research and Training in Complementary and Integrative Health	001	1	9/26/2025	NEW	$170,000
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research and Training in Complementary and Integrative Health	002	1	9/27/2025	NEW	$67,726
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Research and Training in Complementary and Integrative Health	000	1	9/19/2025	NEW	$250,000
														Subtotal = $487,726

Grand Total All Awards = $1,120,004

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Neural Circuitry of Motioninduced Nausea

Award Number: R01AT013056

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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