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A Remotely delivered Tai Chi/Qigong Intervention for older people living with HIV: A Randomized Clinical Trial

Award Number: R01AT012590
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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A Remotely delivered Tai Chi/Qigong Intervention for older people living with HIV: A Randomized Clinical Trial - Project Summary Half of those living with HIV in the United States are over 50 years of age. As people living with HIV (PWH) live longer with the disease, the tradeoff is that they live with multiple comorbidities. One of the more common comorbidities is depression. There is a need to find innovative and accessible nonpharmacological interventions that can help older people living with HIV/AIDS to manage depressive symptoms that may also affect their treatment outcomes. Tai chi/Qigong (TCQ) is a series of slow, low-impact meditative movements that integrate breath work, meditation, and stances; and may improve depressive symptoms. We propose testing the efficacy of a remotely delivered standardized TCQ intervention that has shown to be acceptable and feasible with a population of older people living with HIV/AIDS. Thus, this study proposes three aims: (i) to determine whether a remotely delivered TCQ intervention is directly efficacious in improving depressive symptoms compared to a health education control group among older PWH (50 years of age or older); (ii) to determine whether a remotely delivered TCQ intervention indirectly improves depressive symptoms via biological, psychological, and behavioral mechanisms compared to a health education control group among older PWH and (iii) to determine whether the direct and indirect associations between a TCQ intervention and depressive symptoms is moderated by gender among older PWH. Participants (n=326) will be recruited using social media sites (e.g., WebMD, google, Facebook) throughout the United States, and from at least two contact registries of older PWH. For the registries, research staff will contact participants via phone. All assessments will be conducted via Zoom videoconferencing or phone. Participants will be randomized to 1 of 2 conditions: the TCQ intervention, or a health education control group condition. Both the TCQ and the health education control condition will be delivered via Zoom to participants in the form of live, synchronous classes. We will assess the efficacy of TCQ by looking at instruments that measure depression; and potential mechanisms such as sleep, fatigue, emotional regulation, and heart variability at baseline, 3-month, and 9-month post-intervention. Blood will also be collected via Quest Diagnostics at baseline and at 9-month to collect viral load and an inflammatory marker (C-reactive protein). Data will be described using descriptive techniques. Efficacy of the TCQ treatment will be evaluated using a random effects analysis of covariance (ANCOVA) model. We will follow the Baron & Kenny’s method for mediation analysis to assess if the effect of TCQ intervention on depressive symptoms is mediated by biological (heart variability, using HF power values expected to increase), psychological (emotional regulation, anxiety, stress), and behavioral (fatigue, sleep) variables.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Research and Training in Complementary and Integrative Health	000	2	3/9/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $484,124 )
2025	2025	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Research and Training in Complementary and Integrative Health	001	2	7/7/2025	NON-COMPETING CONTINUATION	$435,711
2025	2025	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Research and Training in Complementary and Integrative Health	002	2	9/9/2025	NON-COMPETING CONTINUATION	$48,413
2025	2024	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Research and Training in Complementary and Integrative Health	000	1	5/1/2025	NEW	$0
														Subtotal = $484,124

Issue Date FY: 2024 ( Subtotal = $492,436 )
2024	2024	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Research and Training in Complementary and Integrative Health	000	1	7/8/2024	NEW	$492,436
														Subtotal = $492,436

Grand Total All Awards = $976,560

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A Remotely delivered Tai Chi/Qigong Intervention for older people living with HIV: A Randomized Clinical Trial

Award Number: R01AT012590

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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