Wednesday, January 15, 2025 1/15/2025

Electroencephalographic biomarkers of response to vibroacoustically-augmented breath-focused mindfulness

Award Number: R01AT011267
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in traumatized people with posttraumatic stress disorder (PTSD), occurs in other disorders including depression, anxiety, and schizophrenia, and is a barrier to recovery in first-line treatments. Dissociation is characterized by attentional impairments and disruptions in body awareness, or interoception. Mindfulness-based meditative practices, including breath-focused mindfulness meditation (BFM), are designed to enhance attentional control through focused awareness on interoceptive cues (breath). However, this is a nearly impossible task for dissociative people, who experience disruptions in body agency and are unable to access or trust body signals. Exteroceptive feedback enhances interoceptive awareness and body agency in experimental studies and may similarly enhance attentional control with minimal cognitive effort. As such, the goal of this study is to address deficits in interoception and attentional control in dissociative traumatized patients via BFM augmented with exteroceptive feedback. This is delivered by a unique device that vibrates in concert with respiration, yielding non-ignorable mechanoreceptor reactivity to breathing. Using a stimulus-driven mechanism, our device is expected to enhance body agency and efficiently engage attention and interoception networks. We will recruit 200 traumatized people with clinically significant dissociation symptoms, divided in four equal groups to yield a 2x2 (breath-focused meditation or rest x with or without vibroacoustic stimulation) design. All participants will attend 8 sessions of their assigned intervention. We will administer attentional control and interoception tasks during fMRI pre- and post-intervention to examine: Aim 1) whether BFM with exteroceptive feedback engages attentional control and interoceptive networks to a significantly greater degree than the other treatment conditions from pre- to post- intervention. We will also examine: Aim 2) whether changes in neural network response correspond with changes in dissociation (and secondarily, other trauma-related problems) to a greater degree in BFM with exteroceptive feedback as compared to the other treatment conditions. The immediate impact of this research is to overcome neurobiological barriers to treatment response in dissociation using novel technology. The long-term impact will be to inform the development of publicly-disseminable devices that can augment current interventi ons.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,002,800 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	001	4	4/12/2024	NON-COMPETING CONTINUATION	$659,189
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	002	4	5/13/2024	NON-COMPETING CONTINUATION	$58,593
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	003	4	7/9/2024	SUPPLEMENT FOR EXPANSION	$285,018
2024	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	000	3	11/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,002,800

Issue Date FY: 2023 ( Subtotal = $768,257 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	003	3	3/10/2023	NON-COMPETING CONTINUATION	$0
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	001	3	2/20/2023	NON-COMPETING CONTINUATION	$732,431
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	002	3	2/27/2023	SUPPLEMENT FOR EXPANSION	$35,826
2023	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	000	2	1/4/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $768,257

Issue Date FY: 2022 ( Subtotal = $877,971 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	001	2	5/6/2022	NON-COMPETING CONTINUATION	$73,082
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	000	2	1/24/2022	NON-COMPETING CONTINUATION	$657,745
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	003	2	9/15/2022	SUPPLEMENT FOR EXPANSION	$111,315
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	002	2	7/18/2022	SUPPLEMENT FOR EXPANSION	$35,829
														Subtotal = $877,971

Issue Date FY: 2021 ( Subtotal = $767,562 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research and Training in Complementary and Integrative Health	000	1	1/19/2021	NEW	$767,562
														Subtotal = $767,562

Grand Total All Awards = $3,416,590

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Electroencephalographic biomarkers of response to vibroacoustically-augmented breath-focused mindfulness

Award Number: R01AT011267

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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