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Synergistic Neuroprotective Mechanisms of Coffee Components in Parkinson's Diseas

Award Number: R01AT006868
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2012
PERIOD OF PERFORMANCE END DATE: 08/31/2017

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Synergistic Neuroprotective Mechanisms of Coffee Components in Parkinson's Diseas - DESCRIPTION (provided by applicant): Coffee is by far the most widely and highly consumed herbal extract. Numerous epidemiological studies indicate that coffee consumption affords reduced risk of Parkinson's disease (PD). This association has been attributed to caffeine, but coffee is much more than just caffeine, and the finding that caffeine may be neuroprotective in no way obviates the possibility that other components in coffee may play a synergistic role with caffeine. We have recently isolated a lipid-like component of coffee, eicosanoyl-5-hydroxytryptamide (EHT), and found it to have a protective effect in mouse models of PD. Biochemical and neuropathological analyses demonstrate that dietary supplementation with EHT leads to decreased 1-synuclein phosphorylation and aggregation, a robust anti-inflammatory effect, and protection against oxidative stress. Studies indicate that the actions of caffeine stem from its antagonism of adenosine A2A receptor signaling, but downstream neuroprotective mechanisms remain to be established. The proposed research will elucidate the molecular mechanisms of neuroprotection mediated by caffeine and EHT as well as their synergy through in vitro biochemical analyses, cell based molecular experiments and in vivo studies in mouse models of PD. The ultimate goal of this work is to develop a dietary supplement(s) or medical food that would slow the progression or prevent the development of neurodegenerative disorders such as PD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	6	2/17/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	001	6	2/28/2017	EXTENSION WITH OR WITHOUT FUNDS	$92,990
2017	2015	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	5	2/28/2017	NON-COMPETING CONTINUATION	-$92,990
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $414,894 )
2016	2016	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	6	8/5/2016	EXTENSION WITH OR WITHOUT FUNDS	$414,894
														Subtotal = $414,894

Issue Date FY: 2015 ( Subtotal = $416,027 )
2015	2015	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	5	8/14/2015	NON-COMPETING CONTINUATION	$416,027
														Subtotal = $416,027

Issue Date FY: 2014 ( Subtotal = $429,017 )
2014	2014	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	002	4	8/15/2014	NON-COMPETING CONTINUATION	$429,017
2014	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	001	1	3/27/2014	NEW	$66,637
2014	2012	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	2	3/24/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$66,637
														Subtotal = $429,017

Issue Date FY: 2013 ( Subtotal = $441,566 )
2013	2013	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Research and Training in Complementary and Integrative Health	002	3	9/12/2013	NON-COMPETING CONTINUATION	$441,566
2013	2012	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Research and Training in Complementary and Integrative Health	001	2	9/5/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$370,136
2013	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	1	9/5/2013	NEW	-$370,136
														Subtotal = $441,566

Issue Date FY: 2012 ( Subtotal = $482,696 )
2012	2012	UMDNJ, ROBERT WOOD JOHNSON MED SCH	335 GEO ST LIBERTY PLAZA 4 FL	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Research and Training in Complementary and Integrative Health	000	1	9/11/2012	NEW	$482,696
														Subtotal = $482,696

Grand Total All Awards = $2,184,200

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Synergistic Neuroprotective Mechanisms of Coffee Components in Parkinson's Diseas

Award Number: R01AT006868

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2012

PERIOD OF PERFORMANCE END DATE: 08/31/2017

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