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Designing biomaterials with temporal control of proteins via genetic fusion with coiled coil peptides for enhanced bone repair

Award Number: R01AR084053
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Designing biomaterials with temporal control of proteins via genetic fusion with coiled coil peptides for enhanced bone repair - Project Summary The use of bone morphogenetic proteins (BMPs) shows promise as therapeutics for improving bone repair; however, high supraphysiological concentrations required for the desired osteoinductive effect, costs, and patient variability have prevented the full advantages of BMP-based therapeutics from being realized. Thus, there is a clinical need to develop new bone tissue engineering approaches that promote osteogenesis at lower BMP doses and prevent adverse side effects. In the native extracellular matrix (ECM), BMP is tightly bound by proteins and glycosaminoglycans with its presentation regulated in time to enhance bioactivity. Furthermore, researchers have shown significant synergies with other signaling molecules, such as cell-matrix or cell-cell adhesion ligands. To mimic these interactions, a number of elegant approaches based on photopatterning and orthogonal chemistries have been developed for presenting biomolecules. However, these approaches rely on highly customized chemical reactions (which may be difficult to implement with full length proteins) and are generally restricted to 1-2 biomolecules. They are also often based on photocleavage reactions for temporal control, which precludes their reversibility over multiple cycles. Given the complexity of the extracellular environment (e.g., the stem cell “niche”) in controlling the fate of cells, a general platform that can control three or more proteins with user-defined, temporal control over protein immobilization would be invaluable for teasing apart the factors that control behavior like cell proliferation, migration, differentiation, and new tissue formation, especially in the context of BMP-induced bone repair. With this in mind, the proposed studies will 1) provide new insight into the temporal role of cell adhesion and growth factor binding during BMP- induced osteogenesis and 2) identify key biomaterial design parameters for promoting bone repair.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $413,655 )
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/25/2025	NEW	$413,655
														Subtotal = $413,655

Grand Total All Awards = $413,655

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Designing biomaterials with temporal control of proteins via genetic fusion with coiled coil peptides for enhanced bone repair

Award Number: R01AR084053

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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