Wednesday, April 2, 2025 4/2/2025

Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skin

Award Number: R01AR081021
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skin - Abstract Highly regenerative tissues such as blood and skin may utilize blood vessels as dual players in tissue growth functions: one in supplying O2/nutrients and another in regulating tissue stem cell activity via signaling. Correlative evidence suggest that skin endothelial cells may act as signaling niches to adult hair follicle stem cells (HFSCs), regulating their quiescence. To demonstrate this, we need gene targeting of signaling molecules in endothelial cells that in turn would affect stem cell activity. Furthermore, recent work on skin vasculature probed a role of lymphatic vessels but not of blood vessels in adult HFSC activation. Finally, the extent of skin vasculature remodeling and its genetic control during the hair cycle are poorly understood. We propose to use a combined genetic and genomic approach in mice to address all these questions. Our mouse models provide an exciting entry point to address the cross- communication of HFSCs with the neighboring endothelial cells, to probe its physiological relevance, and to place endothelial cells for the first time as bona-fide signaling niches for adult HFSCs. This work will have future broad relevance for human skin regeneration studies and for more in depth understanding of skin vasculature disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $419,072 )
2025	2025	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	3/3/2025	NON-COMPETING CONTINUATION	$419,072
														Subtotal = $419,072

Issue Date FY: 2024 ( Subtotal = $452,189 )
2024	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	4/2/2024	NON-COMPETING CONTINUATION	$419,558
2024	2024	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	6/11/2024	NON-COMPETING CONTINUATION	$32,631
														Subtotal = $452,189

Issue Date FY: 2023 ( Subtotal = $472,341 )
2023	2023	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	4/28/2023	NEW	$472,341
														Subtotal = $472,341

Grand Total All Awards = $1,343,602

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Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skin

Award Number: R01AR081021

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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