Wednesday, January 15, 2025 1/15/2025

SCH: Smart User-Effective Data-Enabled (SUEDE) Shoe for Ankle Injury Prevention

Award Number: R01AR080826
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The proposed research is relevant to public health and well aligned with the mission of NIAMS because it addresses the substantial need to improve effectiveness in prevention of ankle sprains, one of the most common musculoskeletal injuries that can significantly impact physical activity and quality of life. While external passive supports, such as ankle taping and bracing, are the most widely used approaches to prevent ankle sprains, their long-term use makes patients overly reliant on the passive and constant support, which leads to ankle muscle and soft tissue atrophy. Furthermore, this approach not only restricts inversion-eversion motion but also dorsiflexion-plantarflexion motion, which in turn may alter natural lower-extremity biomechanics. This project seeks to study a unique smart shoe system, using integrated scientific solutions of engineering, computing and behavioral science, to overcome these limitations and provide enhanced support for individuals at risk of ankle injury. Our specific aims are: (1) to design and implement a smart shoe system that integrates robust, real-time estimation of biomechanical data and activity recognition from wearable sensors with soft actuators capable of actively adjusting the stiffness of the ankle brace; (2) to quantify and model ankle stiffness and foot loading trajectory in healthy individuals as well as in people at risk of ankle sprains; (3) to integrate an injury prediction algorithm and a closed-loop feedback controller that provides active ankle support to prevent sprains; and (4) to refine the developed algorithms for free-living use and design an intuitive mobile user interface that provides summative injury risk metrics in real-time. We will validate and evaluate the proposed smart shoe system by closely engaging with clinical partners to ensure the system is tailored toward optimal clinical integration in mind. The smart shoe system is clinically significant because it will allow clinicians to better understand foot-ankle mechanics and their correlation to ankle injury risk during various physical activities and help them provide effective and summative feedback to the users in a timely manner to promote their adherence to ankle injury prevention strategies. Successful development of the system and rigorous assessment of its patient- and clinic-centered perceived utility will lay the groundwork for follow-up clinical trials specifically aimed at investigating the long-term effect of interventions on preserving/promoting ankle health and enhancing behavioral adherence to clinical recommendations. RELEVANCE (See instructions): This research addresses the substantial need to improve effectiveness in prevention of ankle sprains by introducing a smart shoe system that actively supports the ankle as needed without hindering natural ankle motion and provides an intuitive user interface with injury risk metrics to promote user adherence to clinical prescriptions. This solution is expected to substantially enhance the effectiveness of the current practice of passive ankle bracing or taping and contribute to the long-term goal of promoting ankle health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $246,851 )
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	8/5/2024	NON-COMPETING CONTINUATION	$246,851
														Subtotal = $246,851

Issue Date FY: 2023 ( Subtotal = $258,581 )
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	8/7/2023	NON-COMPETING CONTINUATION	$0
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/4/2023	NON-COMPETING CONTINUATION	$258,581
														Subtotal = $258,581

Issue Date FY: 2022 ( Subtotal = $260,187 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/27/2022	NON-COMPETING CONTINUATION	$260,187
														Subtotal = $260,187

Issue Date FY: 2021 ( Subtotal = $298,404 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/22/2021	NEW	$298,404
														Subtotal = $298,404

Grand Total All Awards = $1,064,023

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SCH: Smart User-Effective Data-Enabled (SUEDE) Shoe for Ankle Injury Prevention

Award Number: R01AR080826

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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