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The Role of the Adrb3/IL6 Axis in the Impact of Psychosocial Stress on Lupus Pathogenesis

Award Number: R01AR080104
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Psychosocial stress has been well-documented to correlate with systemic lupus erythematosus (SLE) flares and poor SLE outcomes. How this occurs has not been well studied. We recently identified that psychosocial stress induces circulating IL6 produced by Adrb3-expressing brown adipocytes. Brown adipocyte-derived IL6 mediates immunometabolic reprogramming through hepatic IL6 signaling to support “fight or flight” responses to acute stress. We have generated preliminary data that chronic psychosocial stress may enhance mortality in murine models of SLE through this novel Adrb3/IL6 pathway. Here, we propose to dissect the role of the Adrb3/IL6 pathway in the impact of psychosocial stress on SLE pathogenesis in murine models. In addition to gaining biological insight into how psychosocial stress leads to increased immune activation in lupus, our studies would provide compelling pre-clinical data for potential human translation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $406,740 )
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	11/30/2023	NON-COMPETING CONTINUATION	$406,740
														Subtotal = $406,740

Issue Date FY: 2023 ( Subtotal = $444,563 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	5/8/2023	NON-COMPETING CONTINUATION	$44,456
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	12/8/2022	NON-COMPETING CONTINUATION	$400,107
														Subtotal = $444,563

Issue Date FY: 2022 ( Subtotal = $444,563 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	1/28/2022	NEW	$444,563
														Subtotal = $444,563

Grand Total All Awards = $1,295,866

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The Role of the Adrb3/IL6 Axis in the Impact of Psychosocial Stress on Lupus Pathogenesis

Award Number: R01AR080104

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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