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Combined Experimental and Analytical Study of the Effects of Zone V Extensor Tendon Injuries on Hand Function

Award Number: R01AR079548
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Extensor tendon injuries of the hand are common and potentially debilitating. The long-term objective of this research is to improve patient outcomes following extensor tendon injury. The first step towards this objective is to determine the effect of extensor tendon injury on patient function. Additional steps can then be taken to improve treatment and outcomes once the underlying causes of poor patient outcomes are known. The first step is the focus of this proposed work. Cadaveric experiments and mathematical modeling will be used to increase our understanding of the effect of extensor tendon injuries on hand function, and to improve treatments for extensor tendon injuries. In the cadaveric experiments the extensor tendons will be loaded to generate finger motion. Tendon excursion, tendon load, grip and finger rotation will be measured during these experiments. There will be two experimental groups with different patterns of extensor injury. Data collected from the first experimental group will be used to create mathematical models relating extensor tendon injury to finger function. The mathematical models will take simulated injury as an input and output finger motion and grip strength. An optimization procedure will be used to generate the models. Given the extensor tendon injury configuration in group one, the optimization will adjust the mathematical model parameters to minimize the difference between model output and group one data. These optimized mathematical models will then be given group two injury configurations as a system input. The accuracy of the mathematical models will be determined by comparing the model’s outputs to data collected from the second experimental group. The effect of extensor tendon injury on finger function will be determined using repeated measures analysis of variance. Accuracy of the mathematical models will be quantified using a similarity metric comparing the second group’s experimental data to the output of the mathematical models using group two’s set of simulated extensor injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $178,032 )
2024	2024	CHICAGO ASSOCIATION FOR RESEARCH & EDUCATION IN SCIENCE	5 TH AVE & ROOSEVELT RD	HINES	IL	60141	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	2/9/2024	NON-COMPETING CONTINUATION	$178,032
														Subtotal = $178,032

Issue Date FY: 2023 ( Subtotal = $226,072 )
2023	2023	CHICAGO ASSOCIATION FOR RESEARCH & EDUCATION IN SCIENCE	5 TH AVE & ROOSEVELT RD	HINES	IL	60141	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	5/8/2023	NON-COMPETING CONTINUATION	$22,607
2023	2023	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5000 S 5TH AVE & ROOSEVELT RD BLDG 1 RM C303	HINES	IL	60141	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/17/2023	NON-COMPETING CONTINUATION	$203,465
														Subtotal = $226,072

Issue Date FY: 2022 ( Subtotal = $226,072 )
2022	2022	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5000 S 5TH AVE & ROOSEVELT RD BLDG 1 RM C303	HINES	IL	60141	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	4/1/2022	NEW	$226,072
														Subtotal = $226,072

Grand Total All Awards = $630,176

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Combined Experimental and Analytical Study of the Effects of Zone V Extensor Tendon Injuries on Hand Function

Award Number: R01AR079548

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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