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Ribosomal control of muscle mass: Transcriptional and epigenetic mechanisms

Award Number: R01AR078430
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Ribosomal control of muscle mass: Transcriptional and epigenetic mechanisms - PROJECT SUMMARY Skeletal muscle plays a fundamental role in health maintenance throughout the lifespan. Loss of muscle mass can have long-lasting deleterious consequences leading to prolonged periods of convalescence and increased mortality. Muscle growth and maintenance are largely determined by the ability of the muscle to synthesize proteins, which in turn is regulated by muscle ribosome. Ribosome production is partly controlled by transcription of ribosomal (r)RNA genes (rDNA) by RNA Polymerase I, and is modulated by the transcriptional suppressors Rb and p130. In this proposal, we seek to understand how the removal Rb and p130 leads to enhanced transcription of rRNA genes and muscle hypertrophy. Using a novel animal model, we report exciting preliminary results indicating that genetic removal of Rb and p130 leads to enhanced ribosome production and skeletal muscle hypertrophy. Using this and other supporting models, we will define novel mechanisms controlling rRNA gene expression by studying the role of transcription and chromatin remodeling factors exerting modulatory functions on rDNA. These studies will significantly advance the field and generate novel targets for the development of therapies to prevent the loss of muscle mass and function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $313,216 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	7/10/2025	NON-COMPETING CONTINUATION	$313,216
														Subtotal = $313,216

Issue Date FY: 2024 ( Subtotal = $337,577 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/18/2024	NON-COMPETING CONTINUATION	$337,577
														Subtotal = $337,577

Issue Date FY: 2023 ( Subtotal = $348,018 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/7/2023	NON-COMPETING CONTINUATION	$348,018
														Subtotal = $348,018

Issue Date FY: 2022 ( Subtotal = $344,538 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/11/2022	NON-COMPETING CONTINUATION	$344,538
														Subtotal = $344,538

Issue Date FY: 2021 ( Subtotal = $348,018 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/22/2021	NEW	$348,018
														Subtotal = $348,018

Grand Total All Awards = $1,691,367

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Ribosomal control of muscle mass: Transcriptional and epigenetic mechanisms

Award Number: R01AR078430

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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