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Integrated Cartilage Repair

Award Number: R01AR073529
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Integrated Cartilage Repair - PROJECT SUMMARY Osteoarthritis, or degeneration of cartilage, is one of the most prevalent joint diseases and remains the most common cause of work-related disabilities in this country. Current osteoarthritis treatment options often fail due to lack of integration between the cartilage graft and the host tissues, including both the surrounding cartilage and underlying bone. Therefore, there exists an unmet clinical need for integrative solutions for cartilage repair. The objective of the proposal is to determine the efficacy of an integrative nanofiber cup system in promoting graft-cartilage and graft-bone integration. It is hypothesized that native cartilage integration will be facilitated by controlling chondrocyte migration to the graft-cartilage junction, and osteointegration will be enhanced by optimizing calcium phosphate (CaP) nanoparticle bioactivity, concentration and spatial distribution. To test this hypothesis, the nanofiber cup system will be evaluated both in vitro (Aims 1 and 2) and in vivo (Aim 3) with a hydrogel-based cartilage graft that exhibits mechanical properties within the range of articular cartilage. An osteochondral explant model will be used to test both graft-cartilage and graft-bone integration in vitro, while a clinically relevant rabbit osteoarthritis model will be used to test host tissue integration in vivo. In addition to evaluating cell and tissue phenotypes via immunohistochemistry and biochemical assays, other functional outcomes such as integration strength and quantitative compositional mapping across tissue boundaries will also be used to determine efficacy in vitro and in vivo. In addition to targeting a clinically significant problem, the proposed approach represents a new paradigm in cartilage repair. The nanofiber integration system is novel because of its: 1) unique nanofiber-based cup design, 2) ability to promote simultaneous graft-cartilage and graft-bone integration, and 3) compatibility with a variety of cartilage grafts. This innovative approach for integrated cartilage repair will enable the restoration of cartilage integrity and long-term function. Moreover, it will help to prevent further joint degeneration and thereby reduce the need for aggressive and often suboptimal interventions (e.g. total joint replacements and related revision surgeries). Successful completion of the planned studies will lead to the development of a new generation of nanotechnology-based fixation devices for the treatment of soft tissue injuries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	2/24/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	6/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $356,760 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	8/2/2022	NON-COMPETING CONTINUATION	$356,760
														Subtotal = $356,760

Issue Date FY: 2021 ( Subtotal = $359,272 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	8/10/2021	NON-COMPETING CONTINUATION	$359,272
														Subtotal = $359,272

Issue Date FY: 2020 ( Subtotal = $353,144 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	7/21/2020	NON-COMPETING CONTINUATION	$353,144
														Subtotal = $353,144

Issue Date FY: 2019 ( Subtotal = $352,484 )
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/1/2019	NON-COMPETING CONTINUATION	$352,484
														Subtotal = $352,484

Issue Date FY: 2018 ( Subtotal = $351,844 )
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/13/2018	NEW	$351,844
														Subtotal = $351,844

Grand Total All Awards = $1,773,504

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Integrated Cartilage Repair

Award Number: R01AR073529

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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