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Utilizing beige fat to improve muscle function after rotator cuff repair

Award Number: R01AR072669
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Utilizing beige fat to improve muscle function after rotator cuff repair - 123 PROJECT DESCRIPTION 45 Rotator cuff (RC) tears are an extremely common cause of shoulder pain and disability. Up to 50% of patients greater than the age of 65 years of age have evidence 6789 of a RC tear. In addition, patients with small asymptomatic cuff tears tend to progress to larger, symptomatic tears. The outcomes of surgical repair of small RC tears are good, but there has been limited success in the surgical treatment of massive RC tears. 11 01 Massive RC tears have been linked with fatty infiltration of the rotator cuff muscles. Patients with large RC tears who develop fatty infiltration have poorer clinical outcomes 11 23 and higher rates of failure after attempted repair. We have previously found that a newly discovered stem cell population-fibro/adipocyte progenitor (FAP) cells-is critical in the 11 45 development of fatty infiltration after RC injury. Further, these cells share similar expression patterns with the beige adipocyte lineage, a distinct cell population that has 11 67 unique thermogenic and metabolic capabilities that could improve muscle function. 11 89 The study will leverage our well-studied animal model and a novel repair model to evaluate the mechanism by which FAP cells can improve muscle function through 22 01 differentiation into a beige fat phenotype in mouse and human tissue. Understanding the relationship between FAP cells and beige adipocytes and utilizing these cells in endogenous and exogenous treatment strategies could help improve muscle quality in RC repair as well as other muscle injury states.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST # 151	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	6/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	11/1/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $742,885 )
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	5	9/23/2022	SUPPLEMENT FOR EXPANSION	$293,450
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	8/10/2022	SUPPLEMENT FOR EXPANSION	$115,548
2022	2022	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	7/29/2022	NON-COMPETING CONTINUATION	$333,887
														Subtotal = $742,885

Issue Date FY: 2021 ( Subtotal = $449,715 )
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	7/22/2021	SUPPLEMENT FOR EXPANSION	$122,573
2021	2021	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/7/2021	NON-COMPETING CONTINUATION	$327,142
														Subtotal = $449,715

Issue Date FY: 2020 ( Subtotal = $337,260 )
2020	2020	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/15/2020	NON-COMPETING CONTINUATION	$337,260
														Subtotal = $337,260

Issue Date FY: 2019 ( Subtotal = $337,260 )
2019	2019	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	5/31/2019	NON-COMPETING CONTINUATION	$337,260
														Subtotal = $337,260

Issue Date FY: 2018 ( Subtotal = $337,260 )
2018	2018	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	8/22/2018	NEW	$0
2018	2018	NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.	4150 CLEMENT ST 151 NC	SAN FRANCISCO	CA	94121	SAN FRANCISCO	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/21/2018	NEW	$337,260
														Subtotal = $337,260

Grand Total All Awards = $2,204,380

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Utilizing beige fat to improve muscle function after rotator cuff repair

Award Number: R01AR072669

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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