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The Ability of MRI to Detect Adverse Local Tissue Reaction and Implant Integration as a Function of Hip Implant Modularity

Award Number: R01AR064840
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Project Summary Total hip arthroplasty (THA) has been successful in achieving pain reduction, but recent concerns have been raised regarding the development of adverse local tissue reactions (ALTRs). Our previous application focused on utilizing MRI as a noninvasive biomarker of ALTR, so that appropriate intervention can be recommended before extensive damage occurs. By evaluating THAs of different bearing materials we found: 1) MRI can detect and distinguish wear debris from THA; 2) MRI is sensitive to ALTR damage from different articulating surfaces; and 3) variable host-mediated response to wear debris mounts distinct morphologic patterns on MRI. There is continued interest in the evaluation of soft tissues near THAs as traditional THA designs, including metal-on-polyethylene (MOP) and ceramic-on-polyethylene (COP) bearing surfaces, have recently been implicated in ALTRs. It is believed that fretting and corrosion at the head-neck junction is responsible for ALTRs, secondary to flexural rigidity and other implant mechanical features. If a greater prevalence of ALTR is found in components with more flexible connections, this could drive the practice of THA to stiffer connections. In this renewal application, we will evaluate two important causes of implant failure: (1) in designs not traditionally associated with ALTRs such as metal-on-polyethylene (MOP) and ceramic-on-polyethylene (COP) we will assess patients indicated for revision THA surgery with MRI and correlate the imaging metrics to targeted biopsy retrieval obtained at the time of revision (including the trunnion), the extent of tissue damage documented at surgery, and implant retrieval analysis of the neck trunnion, including flexural rigidity analysis; and (2) to longitudinally assess implant integration using qualitative MRI evaluation of the bone-implant interface as well as quantitative MRI techniques, T2 mapping and T2* mapping using MAVRIC-UTE, to evaluate relaxometry at the interface.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE HOSPITAL FOR SPECIAL SURGERY FUND, INC.	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	9	3/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $603,820 )
2023	2023	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	9	4/6/2023	NON-COMPETING CONTINUATION	$603,820
														Subtotal = $603,820

Issue Date FY: 2022 ( Subtotal = $636,462 )
2022	2022	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	4/27/2022	NON-COMPETING CONTINUATION	$636,462
														Subtotal = $636,462

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	8/24/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $659,681 )
2020	2020	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	8/24/2020	NON-COMPETING CONTINUATION	$659,681
														Subtotal = $659,681

Issue Date FY: 2019 ( Subtotal = $120,426 )
2019	2019	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	6	7/30/2019	NON-COMPETING CONTINUATION	$120,426
														Subtotal = $120,426

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	12/29/2017	COMPETING CONTINUATION	$770,559
2018	2017	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	5	7/6/2018	COMPETING CONTINUATION	$0
2018	2016	HOSPITAL FOR SPECIAL SURGERY FUND, INC., THE	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	12/29/2017	EXTENSION WITH OR WITHOUT FUNDS	-$770,559
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $681,677 )
2017	2017	THE HOSPITAL FOR SPECIAL SURGERY FUND INC	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	5	9/14/2017	COMPETING CONTINUATION	$681,677
2017	2016	THE HOSPITAL FOR SPECIAL SURGERY FUND INC	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	4	12/13/2016	EXTENSION WITH OR WITHOUT FUNDS	$627,492
2017	2015	THE HOSPITAL FOR SPECIAL SURGERY FUND INC	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	12/13/2016	NON-COMPETING CONTINUATION	-$553,679
2017	2014	THE HOSPITAL FOR SPECIAL SURGERY FUND INC	535 E 70TH ST	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	12/13/2016	NON-COMPETING CONTINUATION	-$73,813
														Subtotal = $681,677

Issue Date FY: 2016 ( Subtotal = $542,996 )
2016	2016	HOSPITAL FOR SPECIAL SURGERY (THE)	525 EAST 71ST STREET, 2ND FLR	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/11/2016	EXTENSION WITH OR WITHOUT FUNDS	$542,996
														Subtotal = $542,996

Issue Date FY: 2015 ( Subtotal = $553,679 )
2015	2015	HOSPITAL FOR SPECIAL SURGERY (THE)	525 EAST 71ST STREET, 2ND FLR	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	7/7/2015	NON-COMPETING CONTINUATION	$553,679
														Subtotal = $553,679

Issue Date FY: 2014 ( Subtotal = $413,171 )
2014	2014	HOSPITAL FOR SPECIAL SURGERY (THE)	525 EAST 71ST STREET, 2ND FLR	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	8/5/2014	NON-COMPETING CONTINUATION	-$312,028
2014	2014	HOSPITAL FOR SPECIAL SURGERY (THE)	525 EAST 71ST STREET, 2ND FLR	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/1/2014	NON-COMPETING CONTINUATION	$725,199
														Subtotal = $413,171

Issue Date FY: 2013 ( Subtotal = $750,507 )
2013	2013	HOSPITAL FOR SPECIAL SURGERY (THE)	525 EAST 71ST STREET, 2ND FLR	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/6/2013	NEW	$749,269
2013	2013	HOSPITAL FOR SPECIAL SURGERY (THE)	525 EAST 71ST STREET, 2ND FLR	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	8/9/2013	NEW	$1,238
														Subtotal = $750,507

Grand Total All Awards = $4,962,419

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The Ability of MRI to Detect Adverse Local Tissue Reaction and Implant Integration as a Function of Hip Implant Modularity

Award Number: R01AR064840

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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