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BONE FORMATION STUDIES BY MAGNETIC RESONANCE MICROSCOPY

Award Number: R01AR051446
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2005
PERIOD OF PERFORMANCE END DATE: 11/30/2010

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BONE FORMATION STUDIES BY MAGNETIC RESONANCE MICROSCOPY - DESCRIPTION (provided by applicant): Many of the diseases affecting today's aging population involve the degeneration of critical skeletal elements, causing chronic pain and loss of mobility. Clearly there is a need to better understand the basics of skeletal biology and its disease pathologies. While skeletal changes during bone development (in children) or bone degeneration (in the elderly) can be studied with X-ray based techniques, these studies measure the mineral content alone and expose healthy subjects to ionizing radiation. What is required is an analytical technique that can non-invasively evaluate the changes that occur in skeletal tissues during skeletogenesis, fracture healing, bone growth into orthopaedic implants, and in response to pharmaceutical interventions. This application proposes a strategy whereby nuclear magnetic resonance (NMR) imaging can be used as a novel non-invasive, non-ionizing means of assessing vertebrate bone formation and repair, providing new measures of these processes and circumventing the invasive and ionizing character of current approaches. This objective will be achieved through the application of the following specific aims: 1) To investigate the efficacy of NMR imaging as a tool for assessing bone formation in a model system based on a hollow fiber bioreactor (HFBR) seeded with primary osteoblast cells; 2) To employ X-ray microtomography (XMT) to establish the ranges of mineral densities for which quantitative NMR parametric maps can be used as surrogate measures of mineral content during bone formation in a HFBR; 3) To employ FT-IR microspectroscopy to establish the range of collagen concentrations for which quantitative NMR maps of the magnetization transfer (MT) effect can be used as a surrogate measure of collagen content for bone formed in a HFBR; and 4) To apply quantitative NMR indices to monitor how collagen and mineral contents change during the bone formation process in a calvarial organ culture system. Our studies, if successful, will yield quantitative, surrogate measures, which can be applied spatially and temporally to monitor the efficacy of different orthopaedic biomaterials, growth factors, bioreactors designs, and mechanical loading conditions on the bone formation process in vitro. Our studies will also yield a novel, non-invasive approach to osteogenesis studies in vivo.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2008	AMERICAN REGISTRY OF PATHOLOGY	14TH ST & ALASKA AVE NW #54	WASHINGTON	DC	20306	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	10/21/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $182,349 )
2008	2008	AMERICAN REGISTRY OF PATHOLOGY	14TH ST & ALASKA AVE NW #54	WASHINGTON	DC	20306	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	2/4/2008	NON-COMPETING CONTINUATION	$182,349
														Subtotal = $182,349

Issue Date FY: 2007 ( Subtotal = $186,071 )
2007	2007	AMERICAN REGISTRY OF PATHOLOGY	14TH ST & ALASKA AVE NW #54	WASHINGTON	DC	20306	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	2/20/2007	NON-COMPETING CONTINUATION	$186,071
														Subtotal = $186,071

Issue Date FY: 2006 ( Subtotal = $191,628 )
2006	2006	AMERICAN REGISTRY OF PATHOLOGY	14TH ST & ALASKA AVE NW #54	WASHINGTON	DC	20306	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/12/2006	NON-COMPETING CONTINUATION	$191,628
														Subtotal = $191,628

Issue Date FY: 2005 ( Subtotal = $196,240 )
2005	2005	AMERICAN REGISTRY OF PATHOLOGY	14TH ST & ALASKA AVE NW #54	WASHINGTON	DC	20306	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	12/30/2004	NEW	$196,240
														Subtotal = $196,240

Grand Total All Awards = $756,288

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BONE FORMATION STUDIES BY MAGNETIC RESONANCE MICROSCOPY

Award Number: R01AR051446

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2005

PERIOD OF PERFORMANCE END DATE: 11/30/2010

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