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Mechanistic analysis of a combined liposome-TLR7/8-agonist adjuvanted virus-like particle vaccine

Award Number: R01AI198147
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/03/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2031

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Mechanistic analysis of a combined liposome-TLR7/8-agonist adjuvanted virus-like particle vaccine - PROJECT SUMMARY Mechanistic analysis of a combined lipid-TLR7/8-agonist adjuvanted virus-like particle vaccine This proposal is focused on elucidating the mechanism of action of combinations of adjuvants in a virus-like particle (VLP) based vaccine. The adjuvant combinations will consist of a TLR7/8 agonist formulated with one of three lipid-based platforms. These platofrms are: 1) AS01-like cationic liposome adjuvant formulation (LAF); 2) MF59-like emulsion adjuvant formulation (EAF); 3) Ionizable lipid nanoparticles (LNPs), The combined adjuvants will be paired with a Powassan virus (POWV)-like particle antigen. We will determine an optimal adjuvant pairing based on elicitation of adaptive immune responses, durability of the response and protection from challenge in a mouse model of virus infection. We will further examine the transcriptional signature of individual cells in the draining lymph nodes of vaccinated animals using single cell RNA sequencing (scRNAseq) with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). Finally, we will extend the results obtained in mice to a non-human primate model, in which we will examine the generation of an immune response as well as lymph node transcriptional signatures post vaccination, allowing comparison of mouse data with an outbred, highly translational model. POWV is a potentially emerging public health threat that is present in much of the northeastern and midwestern United States. Further, we expect that data obtained in this proposal will also be applicable to vaccine design for additional viral pathogens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $769,147 )
2026	2026	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	1	8/3/2026	NEW	$769,147
														Subtotal = $769,147

Grand Total All Awards = $769,147

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Mechanistic analysis of a combined liposome-TLR7/8-agonist adjuvanted virus-like particle vaccine

Award Number: R01AI198147

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/03/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2031

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