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Esx5 secretome in TB and TB-HIV pathogenesis and immunity

Award Number: R01AI192152
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/22/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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Esx5 secretome in TB and TB-HIV pathogenesis and immunity - PROJECT SUMMARY Mycobacterium tuberculosis, the causative agent of human TB, lives exclusively in human cells, and to understand how it causes disease it is important to determine how it delivers its key pathogenic proteins into cells. Using specialized transduction, we generated the only reported complete genetic deletion of the esx5 locus encoding a transport system that is thought to secrete ~150 proteins out of the microbe, and we found that this esx5 mutant is a remarkably good live attenuated vaccine for preventing TB in animal models. In this study we will use our novel esx5 mutant to identify the specific proteins which it secretes, characterize the roles of these secreted proteins in causing disease, and determine the immunologic basis for why the mutant is such a good vaccine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $803,533 )
2026	2026	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Allergy and Infectious Diseases Research	000	2	4/6/2026	NON-COMPETING CONTINUATION	$803,533
														Subtotal = $803,533

Issue Date FY: 2025 ( Subtotal = $820,246 )
2025	2025	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Allergy and Infectious Diseases Research	001	1	8/12/2025	NEW	$0
2025	2025	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Allergy and Infectious Diseases Research	000	1	5/22/2025	NEW	$820,246
														Subtotal = $820,246

Grand Total All Awards = $1,623,779

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Esx5 secretome in TB and TB-HIV pathogenesis and immunity

Award Number: R01AI192152

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/22/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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