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Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance

Award Number: R01AI189831
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance - PROJECT SUMMARY Invasive infections related to the saprophytic mold Aspergillus fumigatus are on the rise, and drug resistance often exacerbates the problem. The mechanisms of fungal adaptation to the azole drugs are not clear. Recently, it has been shown that A. fumigatus can form persistent colonies in response to azole drugs. Long non-coding (lnc)RNAs have been associated with stress adaptation that may eventually lead to resistance. This research team has identified a lncRNA, afu-182, that acts as a negative regulator of azole tolerance. This project will now use innovative approaches to identify the role(s) of afu-182 and delineate the azole response network in A. fumigatus. Aim 1 will characterize the roles of the RTM family of proteins, a class of protein that is involved in ameliorating xenobiotic stress, and define their regulation by afu-182. Aim 2 will study the structure-function relationship of afu-182 to understand the mechanistic basis of afu-182 action. Aim 3 will study a closely related homothallic fungus, Aspergillus nidulans, with a short, defined sexual cycle in an unbiased forward-genetics approach to identify novel factors in azole response. Using a new fundamental paradigm of study, this project will determine the novel mechanisms of azole response in Aspergilli, which will eventually reveal new strategies to combat the rise of azole drug resistance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $418,378 )
2026	2026	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Allergy and Infectious Diseases Research	000	1	4/1/2026	NEW	$418,378
														Subtotal = $418,378

Grand Total All Awards = $418,378

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Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance

Award Number: R01AI189831

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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