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Host lipid acquisition and maintenance of the Chlamydia replicative niche

Award Number: R01AI189455
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/09/2026
PERIOD OF PERFORMANCE END DATE: 01/31/2031

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Host lipid acquisition and maintenance of the Chlamydia replicative niche - SUMMARY Chlamydia trachomatis is the leading cause of sexually transmitted infections of bacterial origin. No vaccine is available. Infections are often asymptomatic, leading to long-term damage of the reproductive organs and deleterious effects on women reproductive health ranging from pelvic inflammatory disease to infertility. The identification and characterization of essential Chlamydia specific factors is paramount to help in the design of effective therapeutics and/or vaccine, but the lag in Chlamydia genetics and the obligate intracellular nature of the pathogens have complicated this process. Here, we identified the first essential Chlamydia inclusion membrane protein. Based on the phenotypes of the corresponding mutant and the link to sphingolipid acquisition, we propose to test the hypothesis that a single Inc protein plays an essential role in preserving the integrity of the replicative niche by mediating the non-vesicular trafficking of sphingolipid to the inclusion and thereby contributes to pathogenesis. Our multidisciplinary approach will provide answers to fundamental biological questions regarding the role of host lipid acquisition in preserving the integrity of the Chlamydia replicative niche and cause disease. Additionally, our studies will reveal how a single Inc protein contribute to this process, thereby reinforcing the potential of these Chlamydia specific proteins as targets to design effective therapeutics and/or vaccines.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $717,952 )
2026	2026	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	1	2/9/2026	NEW	$717,952
														Subtotal = $717,952

Grand Total All Awards = $717,952

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Host lipid acquisition and maintenance of the Chlamydia replicative niche

Award Number: R01AI189455

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/09/2026

PERIOD OF PERFORMANCE END DATE: 01/31/2031

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