Tuesday, August 19, 2025 8/19/2025

Characterization of P. aeruginosa sRNAs that are highly expressed in human chronic infections

Award Number: R01AI187618
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Characterization of P. aeruginosa sRNAs that are highly expressed in human chronic infections - Project Summary Pseudomonas aeruginosa (PA) is an opportunistic pathogen responsible for both acute and chronic infections. These infections, particularly in the case of chronic polymicrobial wounds, are often challenging to eliminate. Our current understanding of the mechanistic aspects of PA polymicrobial wound infection largely stems from experiments conducted in vitro and in animal models. However, the extent to which these models accurately replicate PA functions crucial for human chronic infection remains unclear. In this proposal, the function of two genes (sicX and PA3237) that encode small RNAs highly expressed in human polymicrobial wounds will be elucidated. The overarching hypothesis is that sicX and PA3237 encode sRNAs that post-transcriptionally modulate functions critical for polymicrobial wound infection and antimicrobial tolerance. We will test this hypothesis by: (i) defining the molecular mechanism by which SicX controls its target genes; (ii) elucidating the mechanism(s) controlling SicX-mediated dissemination in the murine surgical wound model; and (iii) identifying the targets of the PA3237 sRNA, focusing on its role in promoting survival to cationic peptide antimicrobials and oxidative stress. This study aims to fill a critical void in our understanding of PA physiology during polymicrobial wound infection, potentially uncovering new diagnostic and therapeutic targets for the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $775,184 )
2025	2025	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Allergy and Infectious Diseases Research	000	1	7/25/2025	NEW	$775,184
														Subtotal = $775,184

Grand Total All Awards = $775,184

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Characterization of P. aeruginosa sRNAs that are highly expressed in human chronic infections

Award Number: R01AI187618

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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