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Molecular characterization and modeling efficient antibody effector function

Award Number: R01AI186995
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/16/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2029

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Molecular characterization and modeling efficient antibody effector function - ABSTRACT Antibody effector functions represent a nexus linking innate and adaptive arms of the immune system and also have direct clinical implications for antibody therapeutics and antibody-mediated pathologies. However, the potency of Ab-dependent effector responses depends on numerous antigen, antibody and effector cell properties. Variable antigen expression levels, accessibility and context on different targets influence not only Ab binding but also the ability of the effector cell to kill or engulf its target. Based on the extensive diversity of natural and engineered antibody forms and formats, both B cells and immunologists can engineer antibodies with different flexibility, affinity, and avidity to manipulate the effector response. The complexity of these interactions makes in vivo experimental testing of all combinations impractical, but the significance of these activities to antibody-based protection and pathology and the opportunity to design agents with a high probability of success once the fundamental cellular presentation mechanisms are understood makes quantitative analysis of this complex biological landscape of high significance. This proposal will elucidate our basic understanding of the cellular mechanisms that can drive advancements in the practical development of immune therapeutics and the parameters by which both B cells and effectors can drive variation in the outcome of antibody recognition. Overall, this work seeks to distill quantitative relationships between antigen, antibody, and effector biology to establish “rules” that enable the generation of antibody design criteria that encapsulate key landmarks in the antibody effector function landscape and enable robust prediction of this critical aspect of antibody activity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $442,024 )
2026	2026	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Allergy and Infectious Diseases Research	000	2	12/5/2025	NON-COMPETING CONTINUATION	$442,024
														Subtotal = $442,024

Issue Date FY: 2025 ( Subtotal = $442,024 )
2025	2025	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Allergy and Infectious Diseases Research	000	1	12/16/2024	NEW	$442,024
														Subtotal = $442,024

Grand Total All Awards = $884,048

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Molecular characterization and modeling efficient antibody effector function

Award Number: R01AI186995

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/16/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2029

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