Monday, August 18, 2025 8/18/2025

Phylodynamic mechanisms of HIV reservoir seeding and maintenance

Award Number: R01AI186721
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2029

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Phylodynamic mechanisms of HIV reservoir seeding and maintenance - PROJECT SUMMARY The HIV reservoir is a population of latently HIV infected cells that persists in people living with HIV on suppressive antiretroviral therapy (ART) and prevents cure of HIV. Dr. Reeves and colleagues will study the mechanisms that create and sustain the HIV reservoir throughout treated and untreated infection. This team will use a mathematical modeling approach to integrate existing published and unpublished as well as novel experimental data ranging across five stages of infection: early and chronic untreated (Aim 1) and early and long-term treated, and analytical treatment interruption (Aim 2). Data will consist of HIV viral loads and genetic sequences (RNA and DNA), cell counts (CD4+ and CD8+ T cells), and clonality of CD4+ T cells defined by T cell receptor sequencing. We will adopt a novel within-host phylodynamic “wiphy” model to specifically study HIV reservoir biology by specifically interrogating the various mechanisms driving its persistence vs. clearance – including cellular proliferation of infected cells and adaptive immune selection against certain HIV sequences. We will determine which mechanisms predominate in which stages, and provide a comprehensive understanding of HIV reservoir creation, maintenance, and evolution throughout all infection stages. This research will aid in the building of next-generation models of HIV reservoir seeding and persistence dynamics. This work will help the HIV cure field gain a deeper understanding of how the HIV reservoir is created during untreated infection and maintained during treated infection. Results should aid in efforts to design therapeutics towards a functional or sterilizing HIV cure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $861,239 )
2025	2025	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	2	8/12/2025	NON-COMPETING CONTINUATION	$861,239
														Subtotal = $861,239

Issue Date FY: 2024 ( Subtotal = $884,322 )
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	1	9/16/2024	NEW	$795,889
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	1	9/19/2024	NEW	$88,433
														Subtotal = $884,322

Grand Total All Awards = $1,745,561

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Phylodynamic mechanisms of HIV reservoir seeding and maintenance

Award Number: R01AI186721

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2029

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