Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

In silico modeling of subcellular infection by diverse families of RNA virus

Award Number: R01AI186222
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/28/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

Group Awards By:

View Award Description

In silico modeling of subcellular infection by diverse families of RNA virus - PROJECT SUMMARY/ABSTRACT RNA viruses are the leading source of existing and emerging pathogens. Many species overtake host cells with just a dozen or so viral components, making subcellular infections tractable for mathematical modeling and analysis. Such models have the potential to identify fragilities in a viral life cycle, examine differences in susceptibility among humans, and serve as templates for reconfiguration in response to novel outbreaks. However, it has not been clear how to build such models in a scalable way, and thus fewer than ten have been developed among the several hundred RNA viruses that infect humans. A new modeling strategy was recently proposed, which starts with a common mass-action topology that is then customized to different virus families by parameter inference. The generic approach lumps together biochemical processes that are specific to different virus families, and it is unclear whether these distinctions are needed to create models that are broadly predictive. The objective of this application is to evaluate the relative merits of generic and familyspecific approaches for modeling subcellular infection by RNA viruses. We focus on coxsackievirus B3 and dengue virus as two species of RNA virus from different families (Picornaviridae and Flaviviridae) for which generic and family-specific models are available or immediately feasible. The overarching hypothesis is that RNA viruses are similarly organized around modules for entry, replication, and other core processes, but the modules fundamentally differ by virus family. The specific aims are to: 1) Compare lumped viral entry to family-specific modules; 2) Refactor the viral replication module; and 3) Add antiviral conduits between modules. Our approach leverages deep transcriptome profiles from several thousand single cells and several hundred relevant human organs; it also invokes a new abstraction (the phase-field crystal model) for a key intermediate of RNA viruses. Computational and experimental tests will be performed using temperature as a system-wide perturbation of biochemical rate parameters at surface (33°C), body (37°C), and febrile (40°C) temperatures. This multi-pronged assessment across different modules will clarify a best-available path toward building foundational models for all major families of RNA viruses that infect humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $542,703 )
2026	2026	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	3	4/3/2026	NON-COMPETING CONTINUATION	$542,703
														Subtotal = $542,703

Issue Date FY: 2025 ( Subtotal = $542,703 )
2025	2025	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	2	4/14/2025	NON-COMPETING CONTINUATION	$542,703
														Subtotal = $542,703

Issue Date FY: 2024 ( Subtotal = $563,593 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	1	5/28/2024	NEW	$508,773
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	1	9/4/2024	NEW	$54,820
														Subtotal = $563,593

Grand Total All Awards = $1,648,999

Top

All Categories

About

Search

Reports

Data Submission

Award Information

In silico modeling of subcellular infection by diverse families of RNA virus

Award Number: R01AI186222

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/28/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer