Tuesday, July 1, 2025 7/1/2025

Human endogenous provirus inhibition of HIV replication

Award Number: R01AI184043
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

Group Awards By:

View Award Description

Human endogenous provirus inhibition of HIV replication - Abstract This application seeks continued support for a new project, based on discoveries made during a research program, funded by the NCI for over 45 years, on biology and evolution of retroviruses and their roles in AIDS and cancer, with a particular focus on Human endogenous retroviruses (HERVs). The studies described in this proposal will ccenter on a provirus in the relatively recent HERV-K (HML-2) group that integrated in a site on chromosome 3, band q12.3 of a common human/gorilla ancestor at least 8 million years ago. In prior work, we discovered that this provirus has several unique features consistent with its having evolved into a restriction factor capable of strongly blocking the virion assembly step in replication both of the reconstructed, infectious, HERV-Kcon and, remarkably, also of HIV. Adaptations to this role include an LTR mutation that leads to widespread expression in all normal human solid tissues and a mutation (or mutations) in the gag CA encoding region that lead to transdominant misassembly of the Gag precursor of the infecting virus at the cell membrane. The current proposal will follow up on these observations with the aims of obtaining a detailed understanding of the mechanism of co assembly and inhibition of HIV Gag assembly and release, understanding the evolution of the 3q12.3 provirus and the scope of its activity against other retroviruses, isolation of HIV escape mutants resistant to 3q12.3 inhibition, and testing the feasibility of using reactivation of the 3q12.3 provirus in HIV target cells as a novel method of prevention of HIV replication.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $694,319 )
2025	2025	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	2	1/15/2025	NON-COMPETING CONTINUATION	$694,319
														Subtotal = $694,319

Issue Date FY: 2024 ( Subtotal = $715,794 )
2024	2024	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	1	2/1/2024	NEW	$644,214
2024	2024	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	1	9/4/2024	NEW	$71,580
2024	2024	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	1	2/14/2024	NEW	$0
														Subtotal = $715,794

Grand Total All Awards = $1,410,113

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Human endogenous provirus inhibition of HIV replication

Award Number: R01AI184043

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer