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Adipocytes and inflammation in the cutaneous leishmaniasis outcome

Award Number: R01AI183392
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/20/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2029

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Adipocytes and inflammation in the cutaneous leishmaniasis outcome - Summary Leishmania braziliensis infection may cause a high spectrum of clinical manifestation, including the more prevalent form, cutaneous leishmaniasis (CL). Inflammatory response is a hallmark of CL and high levels of TNF, IL-1b, and cytotoxicity are associated with skin ulcer development in these individuals. Our preliminary data show that obese CL patients have more severe disease, longer time to heal and high levels of circulating leptin. We will characterize the inflammatory infiltrate observed in the adipose tissue from obese CL patients and determine the role of adipokines in deleterious inflammation in these individuals. Lipid profiles may vary across individuals, and they may be pro-inflammatory or contribute to the healing process. Here we will investigate the lipid profile of obese patients and seek correlation with therapeutic failure in CL. Finally, we will investigate whether lipids associated with tissue healing can reprogram macrophages to a non-inflammatory / tissue repair phenotype. We hypothesize that increased levels of leptin and a particular lipid profile enhance the inflammatory response, leading to poor outcome in obese CL individuals. The overall objective of this proposal is to determine how adipose tissue integrates with the inflammatory response, influencing the severity of CL caused by Leishmania braziliensis, and consequently increasing the rate of therapeutic failure of CL patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $120,226 )
2025	2025	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO	RUA PROFESSOR EDGARD MATA 001	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	2	8/22/2025	NON-COMPETING CONTINUATION	$120,226
														Subtotal = $120,226

Issue Date FY: 2024 ( Subtotal = $120,226 )
2024	2024	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO	RUA PROFESSOR EDGARD MATA 001	SALVADOR				BRA	Allergy and Infectious Diseases Research	000	1	8/20/2024	NEW	$120,226
														Subtotal = $120,226

Grand Total All Awards = $240,452

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Adipocytes and inflammation in the cutaneous leishmaniasis outcome

Award Number: R01AI183392

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/20/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2029

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