Sunday, August 17, 2025 8/17/2025

Development and optimization of a peptide inhibitor of influenza virus splicing for broad-spectrum antiviral therapy

Award Number: R01AI181944
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2029

Group Awards By:

View Award Description

Development and optimization of a peptide inhibitor of influenza virus splicing for broad-spectrum antiviral therapy - PROJECT SUMMARY: In this grant proposal, we aim to develop the L7Ae protein as a therapeutic for treating Orthomyxoviridae family infections. Our approach includes three aims: (1) Investigating the mechanism of action of L7Ae on various family members, focusing on its interaction with the conserved k-turn recognition domain in the L30 RNA- binding proteins, to identify key viral targets and understand how L7Ae disrupts the viral life cycle. (2) Characterizing a recently developed L7Ae transgenic mouse model that shows normal development but resistance to influenza A virus, providing an independent platform to study L7Ae's effects on host and virus biology. (3) Assessing the administration of recombinant L7Ae in vivo by introducing it into mouse lungs and evaluating lung function parameters and histological analyses to examine its impact on lung morphology and inflammation, thereby evaluating potential adverse effects on the host. Our ultimate goal is to generate preclinical data on L7Ae-mediated treatment for Orthomyxoviridae infections, aiming to advance it towards a clinical usage.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,170,096 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	7/23/2025	NEW	$3,170,096
														Subtotal = $3,170,096

Grand Total All Awards = $3,170,096

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development and optimization of a peptide inhibitor of influenza virus splicing for broad-spectrum antiviral therapy

Award Number: R01AI181944

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer