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Immune signatures of vaccine responses in children with sickle cell disease

Award Number: R01AI181379
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2028

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Immune signatures of vaccine responses in children with sickle cell disease - PROJECT SUMMARY/ABSTRACT Our focus is identifying molecular signatures defining sickle cell disease and reduced vaccine response by investigating multiple components of innate immunity and the quality and quantity of long-term adaptive immunity among children with sickle cell disease. We propose a deep interrogation and a systems biology approach to characterize changes in innate and adaptive immunity and whole-genome transcriptional response induced by vaccination in a dysregulated inflammatory milieu linked to poor vaccine response. We have assembled an interdisciplinary investigative group who have an existing successful collaboration infrastructure and has expertise in human immunology, pediatric vaccine response, sickle cell disease, pneumococcal antibody response, proteomics, and computational biology to carry out the proposed studies by 1) examining the innate immune status of children with sickle cell disease; 2) elucidating innate and adaptive signatures of vaccination; 3) defining transcriptomic and proteomic signatures of vaccine response. We will leverage the recent advances in single-cell and spatial immune profiling methods and shared immunologic and proteomic platforms to create a novel resource for sickle cell disease patients and other vulnerable populations. We aim to provide comprehensive mechanistic insights into sickle cell disease-related chronic inflammation and impaired vaccine response that will lead to new interventions to improve clinical outcomes in this understudied pediatric population that have increased morbidity and mortality from infectious diseases and impaired responses to vaccination.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $615,804 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	3	12/10/2025	NON-COMPETING CONTINUATION	$615,804
														Subtotal = $615,804

Issue Date FY: 2025 ( Subtotal = $598,220 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	2	11/7/2024	NON-COMPETING CONTINUATION	$598,220
														Subtotal = $598,220

Issue Date FY: 2024 ( Subtotal = $630,248 )
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	1	11/27/2023	NEW	$568,910
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	001	1	9/4/2024	NEW	$61,338
														Subtotal = $630,248

Grand Total All Awards = $1,844,272

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Immune signatures of vaccine responses in children with sickle cell disease

Award Number: R01AI181379

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2028

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