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Mechanism of macrophages colonization in gonorrhea

Award Number: R01AI179608
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/16/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Mechanism of macrophages colonization in gonorrhea - ABSTRACT The work proposed in this study seeks to investigate the role of macrophages colonization by Neisseria gonorrhoeae (Ng) during infection and the impact on gonorrhea development. Because Ng is a highly human- adapted pathogen, it has developed numerous mechanisms to avoid and actively suppress innate and adaptive immune responses. We uncovered that Ng colonizes and establishes topologically distinct colonies in macrophages. During colonization, Ng manipulates the actin cytoskeleton to invade and create an intracellular niche supportive of bacterial replication. This new model of Ng persistence in macrophages is significant for gonorrhea symptomatology and outcome since the relevant cellular reservoir of bacteria during in vivo infections has yet to be identified. Here we will uncover (1) the host receptors required for macrophages colonization by Ng; (2) bacterial adhesins involved in macrophages colonization; and (3) the role of macrophages colonization by Ng in the context of mucosal immunity in gonorrhea human samples.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $365,000 )
2025	2025	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Allergy and Infectious Diseases Research	000	2	4/18/2025	NON-COMPETING CONTINUATION	$365,000
														Subtotal = $365,000

Issue Date FY: 2024 ( Subtotal = $365,000 )
2024	2024	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Allergy and Infectious Diseases Research	000	1	5/16/2024	NEW	$328,500
2024	2024	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Allergy and Infectious Diseases Research	001	1	5/30/2024	NEW	$36,500
														Subtotal = $365,000

Grand Total All Awards = $730,000

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Mechanism of macrophages colonization in gonorrhea

Award Number: R01AI179608

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/16/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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