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Genomics and sero-epidemiology of Plasmodium falciparum malaria in a pre-elimination setting

Award Number: R01AI176569
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Genomics and sero-epidemiology of Plasmodium falciparum malaria in a pre-elimination setting - PROJECT SUMMARY/ABSTRACT Malaria continues to severely impact public health in countries around the world. Some countries like Ecuador made impressive progress in the first 10-15 years of this century. Nevertheless, recent years have seen stagnation and malaria cases are increasing again. While most cases of Plasmodium falciparum in Northwest Ecuador appear to originate in the Pacific coast of Colombia, asymptomatic reservoirs of this parasite are common and may be important in maintaining transmission within Ecuador. One of the main problems for malaria elimination is the presence of asymptomatic reservoirs. To better understand the malaria transmission dynamics in this pre-eliminating region, we will characterize the genetics of the parasites circulating in northwest Ecuador (symptomatic and asymptomatic), identify serological biosignatures of infection and define the relationships between the clinical outcome of the infection, parasite genetics and serological markers. Lastly, we will validate the role of acquired immunity in disease severity, clonal persistence, and outbreak emergence through innovative in vitro assays. This project will inform local control decisions in Ecuador, and, most importantly, provide a model for understanding disease persistence in other pre-elimination settings around the world.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $136,629 )
2025	2025	PONTIFICIA UNIVERSIDAD CATOLICA DEL ECUADOR	AV. 12 DE OCTUBRE 1076 Y ROCA	QUITO				ECU	Allergy and Infectious Diseases Research	000	3	4/23/2025	NON-COMPETING CONTINUATION	$136,629
														Subtotal = $136,629

Issue Date FY: 2024 ( Subtotal = $135,262 )
2024	2024	PONTIFICIA UNIVERSIDAD CATOLICA DEL ECUADOR	AV. 12 DE OCTUBRE 1076 Y ROCA	QUITO				ECU	Allergy and Infectious Diseases Research	000	2	3/29/2024	NON-COMPETING CONTINUATION	$135,262
														Subtotal = $135,262

Issue Date FY: 2023 ( Subtotal = $129,440 )
2023	2023	PONTIFICIA UNIVERSIDAD CATOLICA DEL ECUADOR	AVENIDA 12 DE OCTUBRE 1076 Y ROCA	QUITO				ECU	Allergy and Infectious Diseases Research	000	1	3/27/2023	NEW	$129,440
														Subtotal = $129,440

Grand Total All Awards = $401,331

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Genomics and sero-epidemiology of Plasmodium falciparum malaria in a pre-elimination setting

Award Number: R01AI176569

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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