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Imaging signatures of early tuberculosis

Award Number: R01AI175555
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/09/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2028

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Imaging signatures of early tuberculosis - ABSTRACT Early detection of tuberculosis (TB) disease to prevent transmission and disability is hampered by the lack of precise biomarkers to diagnose and predict TB progression. The objective of this study is to develop computational imaging tools to characterize and diagnose individuals without TB symptoms who will progress to sputum culture-positive or symptomatic TB disease. In Aim 1, we will combine computed tomography (CT) scans from existing and prospective TB household contact studies to derive a high-resolution radiomic signature to predict and characterize early disease pathology. In Aim 2, we will evaluate methods to enhance performance of field-deployable chest-X-ray computer aided detection (CAD) systems to diagnose early TB using transfer learning, image-to-image training, and integration of clinical and epidemiologic variables. Our goal is to develop a fundamental toolbox for research, diagnosis, and targeted preventive treatment of early TB to prevent transmission and accelerate TB control.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $655,279 )
2026	2026	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	000	3	1/15/2026	NON-COMPETING CONTINUATION	$361,421
2026	2026	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	001	3	1/20/2026	SUPPLEMENT FOR EXPANSION	$293,858
														Subtotal = $655,279

Issue Date FY: 2025 ( Subtotal = $642,787 )
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	000	2	10/25/2024	NON-COMPETING CONTINUATION	$642,787
														Subtotal = $642,787

Issue Date FY: 2024 ( Subtotal = $682,110 )
2024	2024	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	001	1	11/16/2023	NEW	$0
2024	2024	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	000	1	11/9/2023	NEW	$616,750
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Allergy and Infectious Diseases Research	002	1	9/3/2024	NEW	$65,360
														Subtotal = $682,110

Grand Total All Awards = $1,980,176

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Imaging signatures of early tuberculosis

Award Number: R01AI175555

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/09/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2028

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